Evaluation of memory-enhancing effect of flunarizine on active avoidance in experimental model of Alzheimer’s disease through calcium homeostasis

Chandana Kamili
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引用次数: 1

Abstract

Background: Alzheimer’s disease is a chronic, neurodegenerative disease which involves complications in cognitive functioning leading to dementia. Flunarizine (FLN) is a selective, calcium channel blocker that is widely used in the treatment of migraine. Moreover, it was investigated that it can improve cognitive functioning by regulating calcium homeostasis. Objective: The present study aims to evaluate the memory-enhancing effect of FLN in scopolamine-induced dementia model. Materials and Methods: The present study was carried out on male Swiss-albino mice, where Alzheimer’s type of dementia was induced by the administration of scopolamine. In the current investigation, the mice were divided into six groups and then test animals received FLN at the doses of 20 mg, 40 mg, and 80 mg after dosing with scopolamine at the dose of 3 mg/kg, intraperitoneally for 7 days. Active avoidance was assessed by the use of elevated plus maze, T-maze, and Morris Water Maze test. The biochemical markers assessed were acetylcholinesterase, catalase, and lipoxygenase activity. Results: FLN at the doses of 20 mg, 40 mg, and 80 mg showed significantly increased impedance in learning and memory with all the tests. Conclusion: The current study demonstrates significant memory-enhancing effect of FLN.
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通过钙稳态评价氟桂利嗪对阿尔茨海默病实验模型主动回避的记忆增强作用
背景:阿尔茨海默病是一种慢性神经退行性疾病,涉及认知功能并发症导致痴呆。氟桂利嗪(FLN)是一种选择性钙通道阻滞剂,广泛用于治疗偏头痛。此外,研究表明,它可以通过调节钙稳态来改善认知功能。目的:本研究旨在评价FLN对东莨菪碱致痴呆模型的记忆增强作用。材料与方法:本研究采用雄性瑞士白化小鼠,东莨菪碱诱导老年痴呆症。本研究将小鼠分为6组,分别在东莨菪碱以3mg /kg的剂量给药后,腹腔注射20、40、80 mg剂量的FLN,持续7天。采用高架+迷宫、t型迷宫和Morris水迷宫测试评估主动回避。生化指标评估为乙酰胆碱酯酶、过氧化氢酶和脂氧合酶活性。结果:FLN在20、40、80 mg剂量组的学习和记忆阻抗均有明显提高。结论:本研究证实了FLN具有显著的记忆增强作用。
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