Effect of adding Metformin to Insulin therapy in the third trimester of pregnant women with uncontrolled type I Diabetes as regard pregnancy outcome

Abstract

___________________________________________________ Objective: To examine if addition of metformin to insulin is an effective alternative to insulin alone, to lower insulin dose, hospital stay, maternal and neonatal complications in pregnant women at third trimester with uncontrolled type I Diabetes Mellitus, particularly in a resource-poor setting. Material and method: Our randomized controlled trial included 80 patients, who were distributed into two equal groups; group A treated with metformin and insulin and group B treated with insulin alone, in Beni-suef and Cairo University hospitals. Results : We found that metformin and insulin group (Group A) showed