{"title":"The role of oxidative stress in renal injury related to obesity","authors":"D. Pierine, G. Biondo, V. S. Silva, C. Corrêa","doi":"10.14800/ICS.648","DOIUrl":null,"url":null,"abstract":"The mechanisms linking obesity to kidney damage are unknown. The kidney is a target organ for lesions caused by AGEs. The receptor of AGEs (RAGE) has proinflammatory stimuli and appears to play a role in the pathogenesis of renal disease. Thus, treatment with antioxidants can be beneficial for the prevention and therapy of oxidative stress and inflammation in the kidneys resulting from obesity.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":"42 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammation and cell signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/ICS.648","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The mechanisms linking obesity to kidney damage are unknown. The kidney is a target organ for lesions caused by AGEs. The receptor of AGEs (RAGE) has proinflammatory stimuli and appears to play a role in the pathogenesis of renal disease. Thus, treatment with antioxidants can be beneficial for the prevention and therapy of oxidative stress and inflammation in the kidneys resulting from obesity.
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