{"title":"The value of diagnostic model on COVID-19 by Comparing the Features between SARS-COV-2 and other viral infections","authors":"","doi":"10.14800/ics.1197","DOIUrl":"https://doi.org/10.14800/ics.1197","url":null,"abstract":"","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90145977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma level of M-CSF was independently related to 30-day survival in patients with suspected sepsis, and correlated to pathogen load: A prospective cohort study","authors":"","doi":"10.14800/ics.1186","DOIUrl":"https://doi.org/10.14800/ics.1186","url":null,"abstract":"","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82550601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case that high doses of Vitamin C as a potential therapy for COVID-19","authors":"","doi":"10.14800/ics.1169","DOIUrl":"https://doi.org/10.14800/ics.1169","url":null,"abstract":"","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86060223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A study on the significance of anti-endothelial cell antibodies in chronic obstructive pulmonary disease and the effect of methylprednisolone intervention","authors":"","doi":"10.14800/ics.1210","DOIUrl":"https://doi.org/10.14800/ics.1210","url":null,"abstract":"","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83216757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xingqiao Tao, Guohang Yuan, Shanshan Rao, Dan Li, Yaqin Liu, Xiangyan Zhang, Hong Yu, Yongqun He, Xianwei Ye
The detection of viral nucleic acid by real time RT-PCR is the main confirmative diagnostic method for COVID-19 in clinical practice in China and worldwide. However, its sensitivity is unclear. Here we report two cases in a family in Guizhou, southwestern China. The father had a history of long stay in Wuhan. Surprisingly, although the son was diagnosed positive using the nasopharyngeal swab specimen and the rRT-PCR method, the father was diagnosed negative continuously for multiple times. Only after the alveolar lavage fluid sample was used, the father’s rRT-PCR diagnosis turned positive. Their CT diagnosis and clinical symptoms did not completely align with their rRT-PCR diagnostic results. The underlying mechanisms and their implications to clinical practice are discussed.
{"title":"Distinct RT-PCR diagnosis profiles of father and son patients of COVID-19 using nasopharyngeal and alveolar lavage fluid samples","authors":"Xingqiao Tao, Guohang Yuan, Shanshan Rao, Dan Li, Yaqin Liu, Xiangyan Zhang, Hong Yu, Yongqun He, Xianwei Ye","doi":"10.14800/ics.1164","DOIUrl":"https://doi.org/10.14800/ics.1164","url":null,"abstract":"The detection of viral nucleic acid by real time RT-PCR is the main confirmative diagnostic method for COVID-19 in clinical practice in China and worldwide. However, its sensitivity is unclear. Here we report two cases in a family in Guizhou, southwestern China. The father had a history of long stay in Wuhan. Surprisingly, although the son was diagnosed positive using the nasopharyngeal swab specimen and the rRT-PCR method, the father was diagnosed negative continuously for multiple times. Only after the alveolar lavage fluid sample was used, the father’s rRT-PCR diagnosis turned positive. Their CT diagnosis and clinical symptoms did not completely align with their rRT-PCR diagnostic results. The underlying mechanisms and their implications to clinical practice are discussed.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87783502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronavirus disease 2019 (COVID-19) is a novel infectious disease that spreads rapidly around the world and endangers global public health. Because of the lack of specificity of previously identified CT images, such as peripheral and subpleural ground glass opacities, early diagnosis is still a big challenge for radiologists. How to improve the accuracy of diagnosis and make diagnosis as early as possible is a problem concerned by the medical field. This article reports two important CT manifestations in COVID-19 patients
{"title":"Vascular enlargement and bronchiolectasis: Two important CT manifestations in Coronavirus Disease 2019 (COVID-19) and clinicopathologic analysis","authors":"Lei Tang, Xiaoyong Zhang, Yuquan Wang, Rui Xu, Rongpin Wang, Xianchun Zeng","doi":"10.14800/ics.1168","DOIUrl":"https://doi.org/10.14800/ics.1168","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a novel infectious disease that spreads rapidly around the world and endangers global public health. Because of the lack of specificity of previously identified CT images, such as peripheral and subpleural ground glass opacities, early diagnosis is still a big challenge for radiologists. How to improve the accuracy of diagnosis and make diagnosis as early as possible is a problem concerned by the medical field. This article reports two important CT manifestations in COVID-19 patients","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89970547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bangyan Zhang, Xianwei Ye, Li Ma, Li Zhao, Yanju Xu, Shanshan Rao, Xiangyan Zhang, Yiling Tang
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{"title":"COVID-19 pneumonia with night sweat as the first symptom","authors":"Bangyan Zhang, Xianwei Ye, Li Ma, Li Zhao, Yanju Xu, Shanshan Rao, Xiangyan Zhang, Yiling Tang","doi":"10.14800/ics.463","DOIUrl":"https://doi.org/10.14800/ics.463","url":null,"abstract":",","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74981471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Tang, Xiaoyong Zhang, Yuquan Wang, Rongpin Wang, Xianchun Zeng
The coronavirus disease 2019 (COVID-19) has swept across all countries in the world within half a year, which is taking the world by surprise. We reported an elderly, severe, complicated COVID-19 case, describing the clinical manifestations, laboratory examinations, CT findings, diagnosis, treatment and dynamic disease course. 3D post-processing technique was used to reconstruct different pulmonary lesions, and it was found to be useful for highlighting and observing them, thereby helping diagnose and distinguish different diseases.
{"title":"3D post-processing technique highlights lesions: A thought triggered by an elderly, severe, complicated COVID-19 patient","authors":"Lei Tang, Xiaoyong Zhang, Yuquan Wang, Rongpin Wang, Xianchun Zeng","doi":"10.14800/ics.1170","DOIUrl":"https://doi.org/10.14800/ics.1170","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) has swept across all countries in the world within half a year, which is taking the world by surprise. We reported an elderly, severe, complicated COVID-19 case, describing the clinical manifestations, laboratory examinations, CT findings, diagnosis, treatment and dynamic disease course. 3D post-processing technique was used to reconstruct different pulmonary lesions, and it was found to be useful for highlighting and observing them, thereby helping diagnose and distinguish different diseases.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87043252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiological and clinical features of coronavirus disease 2019 (COVID-19) cases in Guizhou Province in Southwest China","authors":"","doi":"10.14800/ics.1150","DOIUrl":"https://doi.org/10.14800/ics.1150","url":null,"abstract":",","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77731395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Esmaeilzadeh, Azita Mohammadzadeh, Nazila Bahmaie
Psoriasis is immune-mediated chronic inflammatory disorder related to Th1 pattern, in which, 2 to 3% of white population worldwide have been affected. It is demonstrated that excessive secretion of pro-inflammatory cytokines such as IL-17A, TNF-α, IL-6, IFN-γ, IL-2 and IL-12 are involved in the immunopathogenesis and clinical manifestations of the disease. Common and previous therapeutics strategies have not been beneficial for all patients, yet. So, there is increasing considerations, leading basic medical scientists toward new directions. During last decade, exponential growth of immune based methods with easy accessibility, less morbidity and operatively yields in clinical trials, has opened a new window to novel clinical applications. Recently, approaches with immunological perspectives such as special immunobiomarkers recruitment, stem cells and vectors have been appropriated to psoriasis immunotherapy purposes. Various evidences suggest that interleukin-35 (IL-35) has important roles in immune system regulation as a promising anti-inflammatory agent. Also, it is demonstrated that Mesenchymal Stem Cells (MSCs) are able to hold anti-inflammatory and immunosuppressive properties, too. Here, we suggest a hypothetical cell and gene-based immunotherapy method that it could be advantageous for pro-inflammatory agents diminution in psoriatic patients. We hope that anti-inflammatory effects of IL-35 gene transfer via Adenoassociated virus as a vector by Bone Marrow derived-MSCs (BM-MSCs) in an Imiquimod-induced psoriasis-like mouse model, will probably be efficient in psoriasis global dilemma domination. Keywords: Psoriasis, IL-35, Mesenchymal stem cell, Regenerative medicine, Clinical applications.
{"title":"New Generation of Promising Immunotherapeutics Approaches for Psoriasis Dilemma; IL-35 Gene as a Potentiated Candidate","authors":"A. Esmaeilzadeh, Azita Mohammadzadeh, Nazila Bahmaie","doi":"10.14800/ICS.1635","DOIUrl":"https://doi.org/10.14800/ICS.1635","url":null,"abstract":"Psoriasis is immune-mediated chronic inflammatory disorder related to Th1 pattern, in which, 2 to 3% of white population worldwide have been affected. It is demonstrated that excessive secretion of pro-inflammatory cytokines such as IL-17A, TNF-α, IL-6, IFN-γ, IL-2 and IL-12 are involved in the immunopathogenesis and clinical manifestations of the disease. Common and previous therapeutics strategies have not been beneficial for all patients, yet. So, there is increasing considerations, leading basic medical scientists toward new directions. During last decade, exponential growth of immune based methods with easy accessibility, less morbidity and operatively yields in clinical trials, has opened a new window to novel clinical applications. Recently, approaches with immunological perspectives such as special immunobiomarkers recruitment, stem cells and vectors have been appropriated to psoriasis immunotherapy purposes. Various evidences suggest that interleukin-35 (IL-35) has important roles in immune system regulation as a promising anti-inflammatory agent. Also, it is demonstrated that Mesenchymal Stem Cells (MSCs) are able to hold anti-inflammatory and immunosuppressive properties, too. Here, we suggest a hypothetical cell and gene-based immunotherapy method that it could be advantageous for pro-inflammatory agents diminution in psoriatic patients. We hope that anti-inflammatory effects of IL-35 gene transfer via Adenoassociated virus as a vector by Bone Marrow derived-MSCs (BM-MSCs) in an Imiquimod-induced psoriasis-like mouse model, will probably be efficient in psoriasis global dilemma domination. Keywords: Psoriasis, IL-35, Mesenchymal stem cell, Regenerative medicine, Clinical applications.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88232019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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