The Role of Oral Cyclosporine in the Management of Steven Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Multicentric Observational Study

Abstract

Background: SJS and TEN are severe life threatening muco-cutaneous reactions characterised by extensive epidermal sloughing with mucosal erosions. Objective: The main objective of this study was to observe the effectiveness of cyclosporine in reducing the mortality and healing time of lesions in patients of SJS and TEN. Methods: The present work was designed as a retrospective tertiary urban hospital based, observational study during the period from March 2019 to Feb 2020. Detailed history, physical examination including cutaneous examination was done at the time of admission and the assessment of lesions using SCORTEN scoring was done at baseline, on day 3 and on tenth day of cyclosporine. All the routine investigations were done in each case. As per hospital records, oral cyclosporine in the dose of 5 mg/kg body weight per day was given to each patient for ten days.