{"title":"Pathogenic bacteria of diabetic-associated infections and their pathogenesis","authors":"S. S. Khazaal, M. Talha, Anmar A. Raheem","doi":"10.1097/MRM.0000000000000222","DOIUrl":null,"url":null,"abstract":"ISSN The diabetic patients have tendencies to develop infections in presence of hyperglycemia makes mucosal epithelial more susceptible to infections. Diabetic mellitus causes a sever deregulation of immune response in a healthy human body. The suppressed production of immune pepetides and altered immune, susceptibility to infections are much higher in immunosuppressed patients with diabetes mellitus. The human host and microorganisms normally exist in a balanced relationship. Infection occurs when pathogens are able to resist host’s immune system and subsequently invade systemic host responses. The reasons why infections do not recover are related to local factors associated with the infections and also with comorbidities such as diabetes. In this review, we discuss the influence of diabetes in bacterial infection and their mechanism emphasizing their role in bacterial pathogensis. Copyright 2020 Wolters Kluwer Health, Inc. All rights reserved.","PeriodicalId":49625,"journal":{"name":"Reviews in Medical Microbiology","volume":"32 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in Medical Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/MRM.0000000000000222","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
ISSN The diabetic patients have tendencies to develop infections in presence of hyperglycemia makes mucosal epithelial more susceptible to infections. Diabetic mellitus causes a sever deregulation of immune response in a healthy human body. The suppressed production of immune pepetides and altered immune, susceptibility to infections are much higher in immunosuppressed patients with diabetes mellitus. The human host and microorganisms normally exist in a balanced relationship. Infection occurs when pathogens are able to resist host’s immune system and subsequently invade systemic host responses. The reasons why infections do not recover are related to local factors associated with the infections and also with comorbidities such as diabetes. In this review, we discuss the influence of diabetes in bacterial infection and their mechanism emphasizing their role in bacterial pathogensis. Copyright 2020 Wolters Kluwer Health, Inc. All rights reserved.
期刊介绍:
Reviews in Medical Microbiology is a quarterly review journal which provides a balanced coverage of the whole field of medical microbiology. The Journal publishes state-of-the art reviews, mini-reviews, case presentations and original research from on-going research of the latest developments and techniques in medical microbiology, virology, mycology, parasitology, clinical microbiology, and hospital infection. In addition, PhD-Review - a platform for young researchers, and biographical Bio-Sketch articles are also considered. Reviews are concise, authoritative, and readable synthesis of the latest information on its subject, and references are limited to the fifty key sources for full reviews and twenty for mini-reviews. Reviews in Medical Microbiology is the perfect way for both qualified and trainee microbiologists, and researchers and clinicians with an interest in microbiology, to stay fully informed of the latest developments in medical microbiology. The journal is a valuable resource for educational and teaching purposes.