Evaluation of Anti-inflammatory Activity of Enriched Boswellia Extract in Human Dermal Fibroblast Cells In-vitro

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-01-01 DOI:10.36648/2321-2748.9.3.16

A. Sudhakar, Shantakumar, Joseph Mv

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引用次数: 0

Abstract

Objective: The enriched Boswellia extract (Olibose®) and Regular Boswellic acid extract (RBAE) prepared from the resin of Boswellia serrata were evaluated for anti-inflammatory activity in Human Dermal Fibroblasts (HDF) Cells In-vitro. Methodolgy: Anti-inflammatory activity was determined by inducing inflammation on HDF and L929 cell lines. After the induction of inflammation, cells were treated with Olibose®, RBAE extracts and standard inflammatory drug Dexamethasone. Levels of Inflammatory markers i.e., TNF-α and NO (Nitric oxide) were measured and anti-inflammatory efficacy was assessed. Results: Results of the present study revealed that, the enriched extract (Olibose®) possess better anti-inflammatory activity in comparison with RBAE. Conclusion: In this study, Olibose® exhibited dose dependant anti-inflammatory activity against LPS induced induction of TNF-α and NO in HDF cells. Olibose® was found to have better anti-inflammatory activity than RBAE in vitro. Since arthiritis/ osteoarthiritis are associated with inflammation, this study proves that Olibose® can be used to reduce above said complications.

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富乳香提取物体外对人真皮成纤维细胞抗炎活性的评价

目的:研究以锯齿状乳香树为原料制备的富乳香树提取物(Olibose®)和普通乳香树酸提取物(RBAE)对人真皮成纤维细胞(HDF)的体外抗炎活性。方法:通过诱导HDF和L929细胞系炎症来测定抗炎活性。诱导炎症后，用Olibose®、RBAE提取物和标准炎症药物地塞米松处理细胞。测量炎症标志物TNF-α和NO(一氧化氮)水平，并评估抗炎效果。结果:本研究结果表明，与RBAE相比，强化提取物(Olibose®)具有更好的抗炎活性。结论:在本研究中，Olibose®对LPS诱导的HDF细胞TNF-α和NO的抗炎活性表现出剂量依赖性。Olibose®在体外被发现比RBAE具有更好的抗炎活性。由于关节炎/骨关节炎与炎症相关，本研究证明Olibose®可用于减少上述并发症。

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来源期刊

American Journal of Phytomedicine and Clinical Therapeutics

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0.50

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