Can Nanotechnology help Push the Limit for Early Cancer Diagnostics

M. Agrawal, Abhijit Biswas
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引用次数: 1

Abstract

J Nanomed Res 2017, 5(1): 00100 connected with it). Therefore, applications of these techniques are limited due to the lack of sufficient sensitivity to detect small numbers of malignant cells in the primary or even metastatic sites [1]. It is also difficult to detect specific cancer cell-surface markers, which are not only a target for cancer therapy but can also assist in the diagnosis and staging of cancer. Other challenges include inadequate drug concentrations reaching the tumor and the limited ability to monitor therapeutic responses thus leading to significant complications such as multidrug resistance due to poor drug delivery [1].
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纳米技术能帮助突破早期癌症诊断的极限吗
纳米材料学报,2017,5(1):00100 [J] .链接本文:因此,由于缺乏足够的灵敏度来检测原发部位甚至转移部位的少量恶性细胞,这些技术的应用受到限制[1]。特异性癌细胞表面标志物的检测也很困难,这些标志物不仅是癌症治疗的靶点,而且还可以帮助癌症的诊断和分期。其他挑战包括到达肿瘤的药物浓度不足以及监测治疗反应的能力有限,从而导致严重的并发症,如由于药物递送不良而产生的多药耐药[1]。
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