Visible-light-enabled multicomponent synthesis of trifluoromethylated 3-indolequinoxalin-2(1H)-ones without external photocatalysis

Letian Zhang , Kai Zheng , Pengfei Zhang , Min Jiang , Jiabin Shen , Chao Chen , Chao Shen
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Abstract

A novel and sustainable visible-light-enabled multicomponent reaction involving quinoxalin-2(1H)-ones, indoles, and CF3SO2Na that does not require an external photocatalyst is described. This photoinduced reaction employs air as the sole oxidant, thereby providing a green and highly step-efficient approach to a series of biologically important trifluoromethylated 3-indolequinoxalin-2(1H)-ones.

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无需外部光催化,利用可见光多组分合成三氟甲基化 3-吲哚喹喔啉-2(1H)-酮
本研究描述了一种无需外加光催化剂的新型可持续可见光多组分反应,该反应涉及喹喔啉-2(1H)-酮、吲哚和 CF3SO2Na。这种光诱导反应采用空气作为唯一的氧化剂,从而为一系列具有重要生物意义的三氟甲基化 3-吲哚喹喔啉-2(1H)-酮的制备提供了一种绿色、高效的方法。
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