Ultrasound Assisted New Imines of 3E-3-(4-Substituted benzylidene)-4-(substituted-1,3,4- thiadiazole-2-ylimino)pentane-2-one and their Antimicrobial Studies

M.B. Zade, S. N. Ibatte
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Abstract

A new series of Schiff bases of 3-(4-substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2- ylimino)pentane-2-one having various substituents of aryl attached to acetoacetone by Knovengel condensation and substituted 1,3,4-thiadiazole were synthesized by using solid supported tetrabutylammonium hydrogen sulfate in microwave irradiation. The synthesized Schiff bases have been evaluated by 1H NMR, elemental analysis, FTIR, mass spectroscopy. All Schiff bases have been screened for their antimicrobial activities. These compounds possess good result of antimicrobial studies.
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超声辅助3E-3-(4-取代苄基)-4-(取代-1,3,4-噻二唑-2-酰基)戊烷-2- 1的新亚胺及其抗菌研究
采用固体负载硫酸氢四丁基铵在微波辐照下合成了一系列新的希夫碱:3-(4-取代苄基)-4-(取代-1,3,4-噻二唑-2-酰基)戊烷-2- 1,具有不同的芳基取代基,通过knovengel缩合与乙酰丙酮和取代1,3,4-噻二唑相连。对合成的席夫碱进行了1H NMR、元素分析、FTIR、质谱等表征。所有的希夫碱都经过了抗菌活性筛选。这些化合物具有良好的抗菌效果。
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