Analysis of a Questionnaire Survey regarding Current Conditions against Exposure to Anticancer Drugs and Reports of Cancer Chemotherapy at Outpatient Departments in Japan

T. Shirakawa, Tomoko Hara, K. Hata, K. Suetsugu, Hideki Kakimoto, K. Ogata, Y. Ikari, H. Sasaki, Makoto Takahashi, M. Fukahori, M. Uoi, T. Esaki, Mikako Hiraike, Toshinobu Hayashi, A. Tokunaga, N. Ureshino, T. Kuwamura, H. Kusaba, K. Mitsugi, E. Baba
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引用次数: 1

Abstract

[Background] Medical staff have many occasions to be exposed to anticancer drugs (ACDs) in the process of performing cancer chemotherapy. Although guidelines for the safe handling of ACDs have been published, actual measures against exposure to ACDs differ between hospitals, and no surveillance data regarding the conditions of each hospital in relation to performing chemotherapy in Japan are available. [Methods] To understand current measures against exposure to ACDs and problems related to cancer chemotherapy at outpatient departments, we conducted a questionnaire survey on doctors, pharmacists, and nurses in 10 leading hospitals for cancer chemotherapy in Japan. [Results] Responses were received from all 10 institutions. The hospital pharmacists prepared all ACDs for outpatients in each institution. All hospitals took basic measures against ACD exposure, such as using personal protective equipment and penetration-resistant waste containers. Conditions against exposure to ACDs generally improved between 2012 and 2015, especially in terms of conveyance of ACDs and use of a closed-system drug transfer device. However, no measures linking ACDs with administration routes or injection sites were commonly taken in any of the hospitals in 2015. [Conclusions] Conditions against ACD exposure improved between 2012 and 2015, possibly because new guidelines were issued. To improve measures for ACD exposure in Japan, preparing more appropriate manuals and offering more opportunities to medical staff for continuing education are considered important.
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日本门诊抗肿瘤药物暴露现状及癌症化疗报告问卷调查分析
【背景】医务人员在进行肿瘤化疗的过程中,多次接触到抗肿瘤药物(ACDs)。虽然已经公布了安全处理促化疗药物的指导方针,但不同医院之间针对促化疗药物的实际措施是不同的,而且没有关于日本每家医院进行化疗的情况的监测数据。【方法】为了解目前门诊抗化疗药物暴露措施及癌症化疗相关问题,我们对日本10家主要癌症化疗医院的医生、药师和护士进行问卷调查。[结果]10所院校均收到了反馈。医院药师为各机构门诊患者准备所有ACDs。所有医院都采取了基本措施防止接触ACD,例如使用个人防护设备和防渗透废物容器。2012年至2015年期间,抗ACDs暴露条件普遍改善,特别是在ACDs输送和使用封闭系统药物输送装置方面。然而,2015年,所有医院普遍没有采取将ACDs与给药途径或注射部位联系起来的措施。【结论】2012年至2015年间,ACD暴露情况有所改善,可能是因为新指南的发布。为了改进日本的抗慢性疼痛药物暴露措施,编写更适当的手册和为医务人员提供更多继续教育的机会被认为是重要的。
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