The Effect of Sports Activity and Vitamin D Intake on Serum Eutoxin-1 and Superoxide Dismutase Levels in Overweight Women with Vitamin D Deficiency: A Clinical Trial Study

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Abstract

Introduction: Being overweight and having vitamin D deficiency are associated with oxidative stress and low-grade chronic inflammation, resulting in various diseases. In the present study, changes in the levels of Eutoxin-1 and superoxide dismutase (SOD) were evaluated after 8 weeks of high-intensity interval resistance training (HIIRT) and vitamin D intake in overweight women with vitamin D deficiency. Method: In this clinical trial study, 52 overweight women with vitamin D deficiency were purposefully selected and then randomly assigned to exercise, vitamin D, exercise+vitamin D (combined), and control groups. HIIRT was performed 3 times a week in three sets with an intensity of 80% of a maximum repetition. Vitamin D was taken at a dose of 50,000 units weekly. Data were analyzed using paired t-test, one-way ANOVA, and Kruskal-Wallis tests with a significant level of less than 0.05. Results: After 8 weeks, SOD activity increased in the experimental groups, and the level of Eutoxin-1 decreased significantly. In addition, the rate of changes in SOD and Eutoxin-1 levels in the combined group was higher than those in the vitamin D group; however, no significant difference was observed between the exercise and combination groups (P<0.05). Conclusion: It seems that HIIRT and vitamin D intake can increase SOD activity and up-regulate Eutoxin-1 in overweight women. Moreover, co-administration of HIIRT with vitamin D intake can have stronger effects in reducing the inflammatory-oxidative effects of overweight and vitamin D deficiency by increasing SOD and decreasing Eutoxin-1, compared to the intervention of vitamin D consumption.
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运动和维生素D摄入对超重维生素D缺乏症妇女血清中Eutoxin-1和超氧化物歧化酶水平的影响:一项临床试验研究
简介:超重和维生素D缺乏与氧化应激和轻度慢性炎症有关,导致各种疾病。在本研究中,我们评估了超重的维生素D缺乏症女性在进行8周高强度间歇阻力训练(HIIRT)和摄入维生素D后Eutoxin-1和超氧化物歧化酶(SOD)水平的变化。方法:本临床试验研究有目的地选择52例超重维生素D缺乏症女性,随机分为运动组、维生素D组、运动+维生素D(联合)组和对照组。HIIRT每周进行3次,分3组,强度为最大重复次数的80%。每周服用5万单位的维生素D。数据分析采用配对t检验、单因素方差分析和Kruskal-Wallis检验,显著性水平小于0.05。结果:8周后,实验组SOD活性升高,Eutoxin-1水平明显降低。此外,联合用药组SOD和Eutoxin-1水平的变化率高于维生素D组;运动组与联合组间差异无统计学意义(P<0.05)。结论:过量摄入HIIRT和维生素D可增加超重女性体内SOD活性,上调Eutoxin-1水平。此外,与维生素D摄入干预相比,HIIRT与维生素D摄入联合使用可以通过增加SOD和降低eutox -1来降低超重和维生素D缺乏症的炎症氧化效应。
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