Molecular Diversity Analysis of the Spike (S) Glycoprotein Gene from Hong Kong-China

Eduarda Doralice Alves Braz Da Silva, Dallynne B rbara Ramos Ven ncio, R. D. Albuquerque, Robson daSilva RamosPierre Teod sio Felix
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Abstract

In this work, 37 haplotypes of spike glycoprotein of SARS-CoV-2 from Hong Kong, China, were used. All sequences were publicly available on the platform of the National Center for Biotechnology Information (NCBI) and were analyzed for their Molecular Variance (AMOVA), haplotypic diversity, mismatch, demographic and spatial expansion, molecular diversity and time of evolutionary divergence. The results suggested that there was a low diversity among haplotypes, with very low numbers of transitions, transversions, indels-type mutations and with total absence of population expansion perceived in the neutrality tests. The estimators used in this study supported the uniformity among all the results found and confirm the evolutionary conservation of the gene, as well as its protein product, a fact that stimulates the use of therapies based on neutralizing antibodies, such as vaccines based on protein S.
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中国香港地区穗(S)糖蛋白基因的分子多样性分析
在这项工作中,使用了来自中国香港的SARS-CoV-2刺突糖蛋白的37个单倍型。所有序列均在美国国家生物技术信息中心(NCBI)平台上公开,并分析其分子方差(AMOVA)、单倍型多样性、错配、人口统计学和空间扩张、分子多样性和进化分化时间。结果表明,单倍型之间的多样性很低,过渡、翻转、indel型突变的数量很低,并且在中性试验中完全没有发现群体扩张。本研究中使用的估计器支持所有发现的结果之间的一致性,并证实了该基因及其蛋白产物的进化保守性,这一事实刺激了基于中和抗体的治疗方法的使用,例如基于蛋白S的疫苗。
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