Small Leucine Rich Proteoglycan in Fibrotic Diseases: New Frenemies?

Jiayu Guo, Yan Wang, Haihai Liang, Baofeng Yang
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Abstract

Review Small Leucine Rich Proteoglycan in Fibrotic Diseases: New Frenemies? Jiayu Guo 1,2, Yan Wang 1,2, Haihai Liang 1,2,3,*, and Baofeng Yang 1,2,3,* 1 Department of Pharmacology (National Key Laboratory of Frigid Zone Cardiovascular Diseases), College of Pharmacy, Harbin Medical University, Harbin 150081, China 2 Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin 150081, China 3 Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China * Correspondence: lianghaihai@ems.hrbmu.edu.cn (H.H.L),; yangbf@ems.hrbmu.edu.cn (B.F.Y)     Received: 27 April 2023 Accepted: 2 June 2023   Abstract: The human body is a complex organism with self-regulating ability and can cope with external pressures and challenges. To protect the body from damage during exercise or confrontations, beneath the human epidermal layer, the human body has evolved a coverall gown: the extracellular matrix (ECM). ECM provides a suitable space for the survival and activity of cells in the body, and affects the behavior of cells through signal transduction system. Proteoglycans, particularly the small leucine rich proteoglycan (SLRP) family, have been shown to be molecules that play important roles in matrix remodeling and organ fibrosis, such as by affecting ECM components or altering the intracellular environment. But in recent years reports of SLRP families, their manifestations in different organs have not been consistent. Recent studies suggest that proteoglycans entering the blood in a soluble form hold promise as diagnostic biomarkers of organ fibrosis and may provide novel therapeutic strategies for fibrotic diseases. Herein, we discuss and review studies of SLRPs in multi-organ fibrotic diseases.
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富含亮氨酸的小蛋白多糖在纤维化疾病中的作用:新的友敌?
富含亮氨酸的小蛋白多糖在纤维化疾病中的作用:新的友敌?郭佳玉1,2,王燕1,2,梁海海1,2,3,*,杨宝峰1,2,3,*1哈尔滨医科大学药学院药学系(寒带心血管疾病国家重点实验室),哈尔滨150081;哈尔滨医科大学黑龙江医学科学院北方转化医学研究合作中心,哈尔滨150081;中国医学科学院,哈尔滨150081 *通讯:lianghaihai@ems.hrbmu.edu.cn (H.H.L),;yangbf@ems.hrbmu.edu.cn (B.F.Y)收稿日期:2023年4月27日收稿日期:2023年6月2日摘要:人体是一个具有自我调节能力的复杂生物体,能够应对外界的压力和挑战。为了保护身体在运动或对抗中免受伤害,在人体表皮层之下,人体进化出了一种全身外衣:细胞外基质(ECM)。ECM为细胞在体内的生存和活动提供了适宜的空间,并通过信号转导系统影响细胞的行为。蛋白聚糖,特别是小亮氨酸富蛋白聚糖(SLRP)家族,已被证明是在基质重塑和器官纤维化中发挥重要作用的分子,例如通过影响ECM成分或改变细胞内环境。但近年来关于SLRP家族的报道,其在不同器官的表现并不一致。最近的研究表明,以可溶性形式进入血液的蛋白多糖有望作为器官纤维化的诊断生物标志物,并可能为纤维化疾病提供新的治疗策略。在此,我们讨论和回顾slrp在多器官纤维化疾病中的研究。
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