PEG-600: Greensolvent for synthesis of pyrazolo[5,1-c]thieno[3,4-e][1,2,4]triazin-6-amine

S. R. Bireddy, Venkata Ramana Reddy Chittireddy, L. Eppakayala
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Abstract

Using polyethylene glycol (PEG-600) as a reaction medium for the synthesis of 3, the green, onepot, multicomponent method was developed. Tandem-prepared compound 3 with excellent yields, without isolation of intermediates in situ. Thus, using PEG-600 as a solvent, novel Pyrazolo[5,1-c]thieno[3,4e][1,2,4]triazine-6-amine(3) products have been prepared with new synthetic routes and techniques.
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PEG-600:合成吡唑[5,1-c]噻吩[3,4-e][1,2,4]三嗪-6-胺的绿色溶剂
以聚乙二醇(PEG-600)为反应介质,开发了绿色、一锅、多组分合成3的方法。串联制备化合物3,产率高,无需原位分离中间体。因此,以PEG-600为溶剂,以新的合成路线和工艺制备了新型吡唑[5,1-c]噻吩[3,4e][1,2,4]三嗪-6-胺(3)衍生物。
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