Preparation and Characterization of Atenolol Laden Nanoparticles

Abstract

In the present study, an attempt was made to develop nanoparticles of Atenolol for effective treatment of Glaucoma. By developing the nanoparticulated delivery the required action of drug at the target site i.e. at eye can be provided. The nanoparticles were prepared by nano precipitation method. The formulation was subjected to different evaluation parameters like particle size, zeta potential, drug content uniformity, entrapment efficiency, in-vitro drug release study.                The particle size range of nanoparticles was found to be 100-256 nm. The zeta potential of nanoparticles was found to be 55.87 to 64.87 mV. The drug content of different formulations F1 to F8 was calculated and the content was found to be in range of 95.98 TO 102.14 %. The entrapment efficiency was found to be in range of 45.76 to 72.98%. From the in-vitro drug release studies, it was found that the cumulative percent drug release for optimised formulation F5 found to be between 12.56 to 88.15 % respectively.