Experimental Shigella Infections in Mice

Abstract

In a previous study the authors reported that Shigilla infection was experimentally induced in miceby oral inoculation of resistant strains of Shigella. This was accomplished by continuous administration ofantibiotics in combination with pre- and post-inoculation of resistance-lowering agents, such as carbon tetrachloride, which were very useful in the establishment of infection. In this connection the authors showedthat in such an infection, the presence of an increase number of antibiotic-resistant organisms, mainly Escherichia coli, due to the effect of chloramphenicol, disrupts the Shigella population.