Miguel Angel González Cardente, Stuart McCulloch, Gerald Pattenden
{"title":"A cascade radical-mediated macrocyclisation–transannulation approach to oestrogen steroids","authors":"Miguel Angel González Cardente, Stuart McCulloch, Gerald Pattenden","doi":"10.1016/S1387-1609(01)01271-3","DOIUrl":null,"url":null,"abstract":"<div><p>A new approach to ring A aromatic steroids, based on cascade 13-<em>endo</em>-<em>trig/dig</em> macrocyclisations followed by sequential 5-<em>exo-trig</em> and 6-<em>exo-trig</em> transannulations, exemplified in the syntheses of the <em>cis,anti,trans</em> tetracycle <strong>9</strong> and the <em>trans,syn</em> tetracycle <strong>13</strong> from the <em>ortho</em>-substituted aryl polyen(yne) precursors, <strong>8</strong> and <strong>12</strong> respectively, is described.</p></div>","PeriodicalId":100305,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","volume":"4 7","pages":"Pages 571-574"},"PeriodicalIF":0.0000,"publicationDate":"2001-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01271-3","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387160901012713","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A new approach to ring A aromatic steroids, based on cascade 13-endo-trig/dig macrocyclisations followed by sequential 5-exo-trig and 6-exo-trig transannulations, exemplified in the syntheses of the cis,anti,trans tetracycle 9 and the trans,syn tetracycle 13 from the ortho-substituted aryl polyen(yne) precursors, 8 and 12 respectively, is described.
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