Comparative Effect of Petroleum Products and Biomass Fuel Exposure on Serum Lipid profile and Atherogenic Indices of male Albino wistar Rats

Abstract

The effects of petroleum products and biomass fuel on serum lipid profile and atherogenic indices were investigated in male wistar rats. Fifty adult male wistar rats were randomly assigned to five groups of ten animals each. Rats in group A served as control (exposed to fresh air). Group B, C, D and E were exposed to inhalation of kerosene, gasoline, liquefied petroleum gas and biomass smoke (wood smoke) respectively. All the exposures were done using whole body exposure chambers 70cm x 60cm x 60cm measurement for six weeks. Five millilitres of fasting blood sample were collected at the end of six weeks and used for analysis of lipid profile using mindray BS 120. Atherogenic indices were calculated using the appropriate formula. Values were analysed statistically using SPSS version 23.0. The result shows significant increase in the serum total, LDL, VLDL cholesterol and triglyceride concentrations of test groups relative to control (p<0.05), while inducing a significant decrease in HDL cholesterol though the effect appear to be more pronounced with kerosene exposure. The exposure also led to significant increase in CRR, AC and AIP (p<0.05). These results suggest that petroleum products and biomass fuel exposure could potentiate the risk of atherosclerosis through elicitation of dyslipidaemia.