J. White, A. Majidi, S. Naser, M. Sweeney, R. S. White
{"title":"Characterization of the Group I Allergen of Bahia Grass Pollen","authors":"J. White, A. Majidi, S. Naser, M. Sweeney, R. S. White","doi":"10.2174/1874838400902010027","DOIUrl":null,"url":null,"abstract":"Four allergenic proteins of Bahia (BA) grass pollen with estimated molecular weights of 45, 33, 31 and 28 kD were previously detected. Although all four proteins were reactive with BA grass allergic patient sera, the 33kD compo- nent was previously verified as a major allergen. The investigators report here for the first time, the similarities between the group I 33 kD allergen of BA grass, Pas n 1, and Group I allergen of Timothy grass, Phl p 1, using N-terminal amino acid sequencing and monoclonal antibodies, IG12 and BOT14, made to Timothy Phl p 1.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"24 1","pages":"27-29"},"PeriodicalIF":0.0000,"publicationDate":"2009-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Allergy Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874838400902010027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Four allergenic proteins of Bahia (BA) grass pollen with estimated molecular weights of 45, 33, 31 and 28 kD were previously detected. Although all four proteins were reactive with BA grass allergic patient sera, the 33kD compo- nent was previously verified as a major allergen. The investigators report here for the first time, the similarities between the group I 33 kD allergen of BA grass, Pas n 1, and Group I allergen of Timothy grass, Phl p 1, using N-terminal amino acid sequencing and monoclonal antibodies, IG12 and BOT14, made to Timothy Phl p 1.
从巴伊亚(Bahia)草花粉中检测到4种致敏蛋白,分子量分别为45、33、31和28 kD。虽然所有四种蛋白都与BA草过敏患者血清有反应,但33kD成分先前被证实是主要的过敏原。本文首次报道了BA草I组33 kD过敏原Pas n 1和Timothy草I组过敏原Phl p 1的相似性,采用n端氨基酸测序和针对Timothy Phl p 1制备的单克隆抗体IG12和BOT14。