Correlation of Serum Vitamin-D Level with Coronary Angiographic Severity In Patients with Acute Coronary Syndrome

Kamruzzaman Siddiki, H. Hoque, Mukhlesur Rahman, F. I. Khaled, Fysal Faruq, M. Alam, A. Kabir, Sayed Nazmul Islam, Azharul Islam, S. Zaman
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Abstract

Background: Acute Coronary Syndrome includes to a group of conditions compatible with acute myocardial ischemia and/or infarction that are usually due to an abrupt reduction in coronary blood flow. In the last decade vitamin-D deficiency as a predisposing factor for coronary artery disease is in growing interest. Prospective studies give conflicting results regarding correlation of serum vitamin D level with coronary angiographic severity in patients with acute coronary syndrome. Objective: To study the correlation between serum vitamin-D level with coronary angiographic severity in patients with acute coronary syndrome. Methodology: This cross sectional observational study was done between November 2018 and October 2019. Total 71 patients with diagnosis of first incident of acute coronary syndrome in department of cardiology, BSMMU who were underwent coronary angiogram included in this study considering the inclusion and exclusion criteria. Vitamin D was measured by chemiluminescent immunoassay after collection of venous blood at Department of Biochemistry, BSMMU. Angiographic severity was assessed by using Gensini score. Statistical analyses were carried out by using the Statistical Package for Social Sciences version 23.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Results: The mean age was found 55.9±10.7 years with a range from 36 to 82 years. Majority (83.1%) patients were male. The male-female ratio was 4.9:1. Thirty (42.3%) of the patients had STEMI, 28(39.4%) had NSTEMI and 13(18.3%) had unstable angina. Negative correlation (r=-0.479; p=0.001) was found between serum vitamin D level and Gensini score in patients with acute coronary syndrome. Conclusion: In this study found that serum vitamin-D level is inversely correlated with angiographic severity in patients with acute coronary syndrome. University Heart Journal Vol. 17, No. 2, Jul 2021; 103-107
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急性冠脉综合征患者血清维生素d水平与冠脉造影严重程度的相关性
背景:急性冠脉综合征包括一组与急性心肌缺血和/或梗死相一致的疾病,通常是由于冠状动脉血流量突然减少。在过去的十年中,维生素d缺乏作为冠状动脉疾病的一个易感因素越来越引起人们的兴趣。关于急性冠脉综合征患者血清维生素D水平与冠状动脉造影严重程度的相关性,前瞻性研究给出了相互矛盾的结果。目的:探讨急性冠脉综合征患者血清维生素d水平与冠脉造影严重程度的相关性。方法:本横断面观察性研究于2018年11月至2019年10月进行。根据纳入和排除标准,本研究共纳入71例在BSMMU心内科首次诊断为急性冠状动脉综合征并行冠状动脉造影的患者。在北京医科大学生物化学系采集静脉血,用化学发光免疫法测定维生素D。采用Gensini评分评估血管造影严重程度。使用Statistical Package for Social Sciences version 23.0 for Windows (SPSS Inc., Chicago, Illinois, USA)进行统计分析。结果:36 ~ 82岁,平均年龄55.9±10.7岁。大多数患者为男性(83.1%)。男女比例为4.9:1。STEMI 30例(42.3%),NSTEMI 28例(39.4%),不稳定型心绞痛13例(18.3%)。负相关(r=-0.479;急性冠脉综合征患者血清维生素D水平与Gensini评分之间存在显著性差异(p=0.001)。结论:本研究发现急性冠脉综合征患者血清维生素d水平与血管造影严重程度呈负相关。《大学心脏杂志》第17卷第2期,2021年7月;103 - 107
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