Allium cepa Inhibits Aspergillus fumigatus Growth and Virulence and Suppresses the Expression of glip Gene Involved in Fungal Pathogenesis

Abstract

gliotoxin production, cell membrane ergosterol content, ultrastructure, and gliP gene expression were evaluated in the fungus exposed to 0.5× MIC concentrations of EAC (1000 μg/mL) and fluconazole (FCZ: 64 μg/mL). Findings: Ergosterol content was significantly reduced to 0.53 and 0.45 µg/mg in EAC-and FCZ-treated fungal cells, respectively ( p < .001). The protease activity was significantly inhibited in both EAC- and FCZ-treated groups. The gliotoxin production was inhibited by 51.55 and 68.75% in the treated groups with FCZ and EAC, respectively. The expression of gliP in both EAC- and FCZ-treated was significantly reduced by 0.40 and 0.53-fold, respectively ( p < .05). Conclusion: This study findings revealed that growth and virulence bioactive Further are recommended to identify