Nabeel M. N. Al-Sharafi, Saja Mazin Radhi Alobaidy
{"title":"Induction of Testicular Degeneration syndrome via Cadmium Chloride in male Albino rats","authors":"Nabeel M. N. Al-Sharafi, Saja Mazin Radhi Alobaidy","doi":"10.36326/kjvs/2022/v13i13709","DOIUrl":null,"url":null,"abstract":"This study was designed to induction of testicular degeneration syndrome (TDS) in male rats by cadmium chloride and identified the best concentration of induction for this syndrome. \nThe effective dose of cadmium chloride (CdCl₂) was determined by used fifteen males rats and where divided into three equal groups treated with CdCl₂ in a concentration (1, 2 and 3)mg/kg B.W. I.P. one /week for two weeks. Later the experimental animals was scarified and testis was took for measuring the antioxidant parameters via evaluated of glutathione GSH, malondialdehyde MDA, catalse, albumin, fructose concentrations and aminotransferase activity (ALT and AST). \nAccording to this result the lowest observed adverse effective dose (LOAEL) of cadmium chloride that induced testicular degeneration in male rats was found to be 1mg/kg B.W. I.p. one /week for two weeks.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kufa Journal For Veterinary Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36326/kjvs/2022/v13i13709","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
This study was designed to induction of testicular degeneration syndrome (TDS) in male rats by cadmium chloride and identified the best concentration of induction for this syndrome.
The effective dose of cadmium chloride (CdCl₂) was determined by used fifteen males rats and where divided into three equal groups treated with CdCl₂ in a concentration (1, 2 and 3)mg/kg B.W. I.P. one /week for two weeks. Later the experimental animals was scarified and testis was took for measuring the antioxidant parameters via evaluated of glutathione GSH, malondialdehyde MDA, catalse, albumin, fructose concentrations and aminotransferase activity (ALT and AST).
According to this result the lowest observed adverse effective dose (LOAEL) of cadmium chloride that induced testicular degeneration in male rats was found to be 1mg/kg B.W. I.p. one /week for two weeks.