Pub Date : 2023-06-30DOI: 10.36326/kjvs/2023/v14i110853
Fatima Saad, Iman Ibrahim Dle
One of the organs that can be found in the abdominal cavity is called the pancreas. It is a vital component in the process by which the food we eat is transformed into fuel for the cells of the body. For investigation of morphological description of the pancreas, the study was performed on twenty adult swan geese (10 males and 10 females). According to the morphological findings, the pancreas of geese was located on the right side of their abdominal cavity. It possessed four lobes—dorsal, splenic, ventral, and third and a distinctive duodenal papilla. It was between the ascending and descending duodenal loops. The goose pancreas has a thin covering of connective tissue over its mesothelium. The pancreatic parenchyma was divided by connective tissue septa, into numerous lobules, and these lobules extended outward from the pancreatic capsule. There was a wide range of diameters for the blood vessels. It consists of significant blood arteries, which can be identified by their oval or circular, bright nuclei. They have oval or circular, brilliant nuclei with the nucleolus. In the swan goose, serous acini and islets of Langerhans made up most of the pancreatic parenchyma. Exocrine cells had pyramidal shapes, acidophilic granules, and serous acini. In conclusion, the pancreas of geese like the most bird and is different from domestic animals.
{"title":"Morphological description of the pancreas in male and female swan geese","authors":"Fatima Saad, Iman Ibrahim Dle","doi":"10.36326/kjvs/2023/v14i110853","DOIUrl":"https://doi.org/10.36326/kjvs/2023/v14i110853","url":null,"abstract":"One of the organs that can be found in the abdominal cavity is called the pancreas. It is a vital component in the process by which the food we eat is transformed into fuel for the cells of the body. For investigation of morphological description of the pancreas, the study was performed on twenty adult swan geese (10 males and 10 females). According to the morphological findings, the pancreas of geese was located on the right side of their abdominal cavity. It possessed four lobes—dorsal, splenic, ventral, and third and a distinctive duodenal papilla. It was between the ascending and descending duodenal loops. The goose pancreas has a thin covering of connective tissue over its mesothelium. The pancreatic parenchyma was divided by connective tissue septa, into numerous lobules, and these lobules extended outward from the pancreatic capsule. There was a wide range of diameters for the blood vessels. It consists of significant blood arteries, which can be identified by their oval or circular, bright nuclei. They have oval or circular, brilliant nuclei with the nucleolus. In the swan goose, serous acini and islets of Langerhans made up most of the pancreatic parenchyma. Exocrine cells had pyramidal shapes, acidophilic granules, and serous acini. In conclusion, the pancreas of geese like the most bird and is different from domestic animals.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87325826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.36326/kjvs/2023/v14i112070
Hayder Hasan Khudiar, Saadia Saleh Mehdy
This study was carried out to investigate the potential of crude ethanolic extracts of eggplant (Solanum melongena) peels, fruit, and seeds, as well as dry eggplant, in the treatment of hyperlipidemia in rats. Forty-nine adult female Sprague Dawley rats were used with a weighting between (280-340) grams. Following the establishment of hyperlipidemia by providing them with a high-fat diet consisting of 4% cholesterol with 5% egg yolk for a period of 30 days in all groups except the control negative. Afterward, the rats were divided into seven groups of 7 rats as followed: The first group control negative was given standard pellets and water only, and the second group control positive induction hyperlipidemia this applied to all groups. Other groups (third, fourth, and five) were administered with alcoholic extracts of Solanum Melongena parts including the peel group, fruit group, and seed group, at a dose of 400 mg/kg/B.W. orally once a day, and group six received dry eggplant without extract at a dose of 200 mg/kg/diet once daily. The seven groups received atorvastatin at a dose of 20 mg/ B.W. orally once daily for a period of 45 days for all groups. The results of the study on serum lipid profile in rats indicated that the peel and atorvastatin groups exhibited a significant decrease in levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and low-density lipoprotein (VLDL). Furthermore, the peel and atorvastatin groups had substantially elevated high-density lipoprotein (HDL) levels. The study suggests that eggplant peel extract and atorvastatin, a common drug, can potentially treat hyperlipidemia in rats.
{"title":"Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats","authors":"Hayder Hasan Khudiar, Saadia Saleh Mehdy","doi":"10.36326/kjvs/2023/v14i112070","DOIUrl":"https://doi.org/10.36326/kjvs/2023/v14i112070","url":null,"abstract":"This study was carried out to investigate the potential of crude ethanolic extracts of eggplant (Solanum melongena) peels, fruit, and seeds, as well as dry eggplant, in the treatment of hyperlipidemia in rats. Forty-nine adult female Sprague Dawley rats were used with a weighting between (280-340) grams. Following the establishment of hyperlipidemia by providing them with a high-fat diet consisting of 4% cholesterol with 5% egg yolk for a period of 30 days in all groups except the control negative. Afterward, the rats were divided into seven groups of 7 rats as followed: The first group control negative was given standard pellets and water only, and the second group control positive induction hyperlipidemia this applied to all groups. Other groups (third, fourth, and five) were administered with alcoholic extracts of Solanum Melongena parts including the peel group, fruit group, and seed group, at a dose of 400 mg/kg/B.W. orally once a day, and group six received dry eggplant without extract at a dose of 200 mg/kg/diet once daily. The seven groups received atorvastatin at a dose of 20 mg/ B.W. orally once daily for a period of 45 days for all groups. The results of the study on serum lipid profile in rats indicated that the peel and atorvastatin groups exhibited a significant decrease in levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and low-density lipoprotein (VLDL). Furthermore, the peel and atorvastatin groups had substantially elevated high-density lipoprotein (HDL) levels. The study suggests that eggplant peel extract and atorvastatin, a common drug, can potentially treat hyperlipidemia in rats.\u0000 ","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80866783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.36326/kjvs/2023/v14i110923
Hanan Waleed Kasim Aqwaan
Reproductive function is the cornerstone in achieving better profitability for sheep; researchers have developed several ways to guide the reproduction of ewes and develop their reproductive efficiency by its needs. This contributed to reducing the vaccination season and the timing of births in ewes during a limited year to provide optimal care conditions. The optimal use of these techniques in the reproductive function enables us to enter estrus, increase the ovulation rate, and the appropriate timing of artificial insemination, which in turn increases the reproductive efficiency of ewes. Therefore, it has become necessary to use modern biotechnologies such as estrus synchronization technology, which is one of the technologies that help reduce the time and effort required to detect estrus by collecting estrus cases in treated animals. By applying reproductive care programs such as synchronizing estrus and increasing fertility using compounds such as injections of human chorionic gonadotropin, gonadotropin-releasing hormone or progesterone after mating and prostaglandin F2alpha, prostaglandin E and melatonin hormone, it may help to be performed at a specific time
{"title":"The Role of Certain Specific Hormonal Treatments in Estrus Synchronization of Ewes: A mini Review","authors":"Hanan Waleed Kasim Aqwaan","doi":"10.36326/kjvs/2023/v14i110923","DOIUrl":"https://doi.org/10.36326/kjvs/2023/v14i110923","url":null,"abstract":"Reproductive function is the cornerstone in achieving better profitability for sheep; researchers have developed several ways to guide the reproduction of ewes and develop their reproductive efficiency by its needs. This contributed to reducing the vaccination season and the timing of births in ewes during a limited year to provide optimal care conditions. The optimal use of these techniques in the reproductive function enables us to enter estrus, increase the ovulation rate, and the appropriate timing of artificial insemination, which in turn increases the reproductive efficiency of ewes. Therefore, it has become necessary to use modern biotechnologies such as estrus synchronization technology, which is one of the technologies that help reduce the time and effort required to detect estrus by collecting estrus cases in treated animals. By applying reproductive care programs such as synchronizing estrus and increasing fertility using compounds such as injections of human chorionic gonadotropin, gonadotropin-releasing hormone or progesterone after mating and prostaglandin F2alpha, prostaglandin E and melatonin hormone, it may help to be performed at a specific time","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73535031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.36326/kjvs/2023/v14i110352
Aaya Sabah Abdulhur, B. Hamza Fares
The Annona muricata (Family-Annonaceae) fruit contain annonaceous acetogenins which have an effect on cancer cell as reported in many research studies. This study was aimed to evaluate the effect of methanolic fruit extract of Annona muricata (MFEAM) on breast cancer histology and invasive cell of MNU-induced breast cancer mice. Fifty female albino mice were divided into five groups (of ten each): control; MNU-induced breast cancer; MNU-induced breast cancer + (MFEAM) 200 mg/kg, MNU-induced breast cancer + (MFEAM) 300 mg/kg and MNU-induced breast cancer + (MFEAM) 500 mg/kg. The research indicates that breast cancer invasive ductal carcnoma (IDC) developed in the MNU-induced breast cancer group. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group. We concluded that (MFEAM), that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose was 300 mg/kg. The present study concluded that the methanol extracts derived from Annona muricata fruit potentially exhibit antitumor activity. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group, We concluded (MFEAM) that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose in 300 mg/kg.
{"title":"Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice","authors":"Aaya Sabah Abdulhur, B. Hamza Fares","doi":"10.36326/kjvs/2023/v14i110352","DOIUrl":"https://doi.org/10.36326/kjvs/2023/v14i110352","url":null,"abstract":"The Annona muricata (Family-Annonaceae) fruit contain annonaceous acetogenins which have an effect on cancer cell as reported in many research studies. This study was aimed to evaluate the effect of methanolic fruit extract of Annona muricata (MFEAM) on breast cancer histology and invasive cell of MNU-induced breast cancer mice. Fifty female albino mice were divided into five groups (of ten each): control; MNU-induced breast cancer; MNU-induced breast cancer + (MFEAM) 200 mg/kg, MNU-induced breast cancer + (MFEAM) 300 mg/kg and MNU-induced breast cancer + (MFEAM) 500 mg/kg. The research indicates that breast cancer invasive ductal carcnoma (IDC) developed in the MNU-induced breast cancer group. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group. We concluded that (MFEAM), that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose was 300 mg/kg. The present study concluded that the methanol extracts derived from Annona muricata fruit potentially exhibit antitumor activity. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group, We concluded (MFEAM) that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose in 300 mg/kg.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87178565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.36326/kjvs/2023/v14i111158
Orooba M.S. Ibrahim, Ban M. Ali
Fungal infection is a serious health problem, involved with the life threatening mycosis and mortality. Emerging of resistance and limited antifungal drugs against most antifungal agents lead to the requirement for development of effective and alternate strategies to fight fungal infections. The aim of this study is to investigate the antifungal activity of clove oil extract against systemic induced infection In vivo by Candida albicans in mice. Fifty mice were used to induce systemic infection by injecting 1 ml of 1×106 C.albicans suspension intra-peritoneally for seven days consecutive, then sacrificed to observe the incidence of infection in internal organs (gross lesion) and measure the level of IL-6 and serum creatinine plus histopathological changes. The development of systemic infection with C. albicans (1 × 106 cells) was observed daily for 14 days which was accompanied with clinical signs of infection, including weight loss, depression, and ruffled appearance. IL-6 level showed no significant difference in all group before treatment and after inducing infection the level of IL-6 showed significant increase (P≤0.01) in control positive group while group treated with clove oil 5 mg/kg and 10 mg/kg showed significant decrease in the level compared with infected group and fluconazole treated group . Serum creatinine concentration was within the normal values in all groups (p>0.01) before the infection. There were an increase significantly (P≤0.01) in the level in all infected mice after 7 days of infection. The serum creatinine values of treated group with clove oil extract 5 mg/kg and 10 mg/kg showed decreased in the creatinine concentration . The present results demonstrated that the essential oil of clove extract rich with eugenol has great antifungal power. This extract can be suggested as antimicrobial and antifungal to treat candidemia and reduce the incidence of mortality rate due to systemic candidiasis.
{"title":"Antifungal potency of clove (Syzygium aromaticum) essential oil extract against induced systemic infection by Candida albicans in mice","authors":"Orooba M.S. Ibrahim, Ban M. Ali","doi":"10.36326/kjvs/2023/v14i111158","DOIUrl":"https://doi.org/10.36326/kjvs/2023/v14i111158","url":null,"abstract":"Fungal infection is a serious health problem, involved with the life threatening mycosis and mortality. Emerging of resistance and limited antifungal drugs against most antifungal agents lead to the requirement for development of effective and alternate strategies to fight fungal infections. The aim of this study is to investigate the antifungal activity of clove oil extract against systemic induced infection In vivo by Candida albicans in mice. Fifty mice were used to induce systemic infection by injecting 1 ml of 1×106 C.albicans suspension intra-peritoneally for seven days consecutive, then sacrificed to observe the incidence of infection in internal organs (gross lesion) and measure the level of IL-6 and serum creatinine plus histopathological changes. The development of systemic infection with C. albicans (1 × 106 cells) was observed daily for 14 days which was accompanied with clinical signs of infection, including weight loss, depression, and ruffled appearance. IL-6 level showed no significant difference in all group before treatment and after inducing infection the level of IL-6 showed significant increase (P≤0.01) in control positive group while group treated with clove oil 5 mg/kg and 10 mg/kg showed significant decrease in the level compared with infected group and fluconazole treated group . Serum creatinine concentration was within the normal values in all groups (p>0.01) before the infection. There were an increase significantly (P≤0.01) in the level in all infected mice after 7 days of infection. The serum creatinine values of treated group with clove oil extract 5 mg/kg and 10 mg/kg showed decreased in the creatinine concentration . The present results demonstrated that the essential oil of clove extract rich with eugenol has great antifungal power. This extract can be suggested as antimicrobial and antifungal to treat candidemia and reduce the incidence of mortality rate due to systemic candidiasis.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77916323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.36330/kmj.v19i1.11356
Rabie Alagib Abdallah, Mohamed Abdelrhaman Altahir, Reem Tajelsir Ali, Amar Mohamed Ismail, Abuagla M. Dafalla, Hani M. Abdalla, G. Modawe
Background: One of the main risk factors for cardiovascular illnesses and a widespread health issue, is hypertension which can result in improper calcium metabolism. Vitamin D may lessen the prevalence of hypertension as it has been suggested that rickets and osteomalacia are frequently brought on by vitamin D insufficiency. Objective: the present study aims to assess bone minerals density in hypertensive patients with vitamin D deficiency. Materials and Methods: this is a cross-sectional study conducted in April through June of 2019. Eighty-eight hypertension patients were included in the study, 46 men and 42 women, and they were divided into two groups depending on their vitamin D results: normal, >20 ng/ml, and case, 20 ng/ml. The data were analyzed by using SPSS version20. Serum vitamin D level was determined by using an ELISA competitive assay, serum ALP and Mg level was determined by using spectrophotometric methods, and serum Ca and Ph level was determined by using dye colorimetric methods. Results: Females, overweight subjects and more than 5 years patients showed a decrease in vitamin D level, with P-values (0.000, 0.003 and 0.041) respectively. The mean serum level of ALP and Mg were significantly increased in overweight group (P-values 0.048 and 0.041). The mean serum levels of ALP, Ca, Ph and Mg showed insignificant differences in the study group classified based on gender P-values (0.844, 0.546, 0.173 and 0.716) respectively. Patients with long history of disease (> 5 years) have significant increase in Ca levels p-value (0.019). Conclusion Patients with obesity have lower vitamin D levels, while having higher levels of ALP and Mg. Patients with long histories of disease (> 5 years) have higher levels of Ca. Females are more susceptible to vitamin D deficiency. There is no discernible difference in serum ALP, calcium, phosphate, or magnesium between hypertensive patients with normal or lower of levels vitamin D.
{"title":"Assessment Of Bone Minerals Density Among Vitamin D Deficient Hypertensive Patients","authors":"Rabie Alagib Abdallah, Mohamed Abdelrhaman Altahir, Reem Tajelsir Ali, Amar Mohamed Ismail, Abuagla M. Dafalla, Hani M. Abdalla, G. Modawe","doi":"10.36330/kmj.v19i1.11356","DOIUrl":"https://doi.org/10.36330/kmj.v19i1.11356","url":null,"abstract":"Background: One of the main risk factors for cardiovascular illnesses and a widespread health issue, is hypertension which can result in improper calcium metabolism. Vitamin D may lessen the prevalence of hypertension as it has been suggested that rickets and osteomalacia are frequently brought on by vitamin D insufficiency. Objective: the present study aims to assess bone minerals density in hypertensive patients with vitamin D deficiency. Materials and Methods: this is a cross-sectional study conducted in April through June of 2019. Eighty-eight hypertension patients were included in the study, 46 men and 42 women, and they were divided into two groups depending on their vitamin D results: normal, >20 ng/ml, and case, 20 ng/ml. The data were analyzed by using SPSS version20. Serum vitamin D level was determined by using an ELISA competitive assay, serum ALP and Mg level was determined by using spectrophotometric methods, and serum Ca and Ph level was determined by using dye colorimetric methods. Results: Females, overweight subjects and more than 5 years patients showed a decrease in vitamin D level, with P-values (0.000, 0.003 and 0.041) respectively. The mean serum level of ALP and Mg were significantly increased in overweight group (P-values 0.048 and 0.041). The mean serum levels of ALP, Ca, Ph and Mg showed insignificant differences in the study group classified based on gender P-values (0.844, 0.546, 0.173 and 0.716) respectively. Patients with long history of disease (> 5 years) have significant increase in Ca levels p-value (0.019). Conclusion Patients with obesity have lower vitamin D levels, while having higher levels of ALP and Mg. Patients with long histories of disease (> 5 years) have higher levels of Ca. Females are more susceptible to vitamin D deficiency. There is no discernible difference in serum ALP, calcium, phosphate, or magnesium between hypertensive patients with normal or lower of levels vitamin D.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90340898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.36330/kmj.v19i1.11076
Anmar Abdullah Jassim Alhamadani, Ghassan Mohammad Ahmed Alrawy, Ahmed Saadallah Ahmed Alhankawi, Samet Almoula
Background: Sensorineural hearing loss are common neurological deficit, and diabetes mellitus is a common cause for these problems. Hearing impairment affects the quality of life of diabetic patients. Many researchers found hearing impairment in diabetic patients because diabetes mellitus can cause sensorineural hearing loss (SNHL) because of neuropathy and microvascular complications of diabetes mellitus. Aim of the study: The study aims to sensorineural hearing loss in diabetic patients compared with non-diabetic control. Patients and methods: A prospective case control study is performed during the period between Jan 2018 and May 2019. This case series study included 100 known cases of diabetes mellitus, their ages were between 20-60 years, treated at Al-wafaa center, which is specialized center for treatment and follow up of diabetic patients, and Al-Jumhory Teaching Hospital in Mosul. The control group included 100 individuals who did not have any diabetes mellitus or any of the exclusion criteria mentioned in the study. Results: It has been found that sensorineural hearing loss (SNHL) was more common in diabetic patients group than controls group, 21% versus 8%. The prevalence of (SNHL) was more in male 31.7% than female diabetic patients 13.5%. Hearing threshold in diabetic patients was higher than that in control group. The hearing loss in diabetic patients is slowly progressive and directly related to the duration of diabetes. Conclusions: Sensorineural hearing loss has been found to be more common in diabetic patients than in control group, and the hearing loss in diabetic patients is slowly progressive. The hearing threshold in diabetic patients had a direct correlation with the duration of disease.
{"title":"Sensorineural Hearing Loss in Diabetes Mellitus","authors":"Anmar Abdullah Jassim Alhamadani, Ghassan Mohammad Ahmed Alrawy, Ahmed Saadallah Ahmed Alhankawi, Samet Almoula","doi":"10.36330/kmj.v19i1.11076","DOIUrl":"https://doi.org/10.36330/kmj.v19i1.11076","url":null,"abstract":"Background: Sensorineural hearing loss are common neurological deficit, and diabetes mellitus is a common cause for these problems. Hearing impairment affects the quality of life of diabetic patients. Many researchers found hearing impairment in diabetic patients because diabetes mellitus can cause sensorineural hearing loss (SNHL) because of neuropathy and microvascular complications of diabetes mellitus.\u0000Aim of the study: The study aims to sensorineural hearing loss in diabetic patients compared with non-diabetic control.\u0000Patients and methods: A prospective case control study is performed during the period between Jan 2018 and May 2019. This case series study included 100 known cases of diabetes mellitus, their ages were between 20-60 years, treated at Al-wafaa center, which is specialized center for treatment and follow up of diabetic patients, and Al-Jumhory Teaching Hospital in Mosul. The control group included 100 individuals who did not have any diabetes mellitus or any of the exclusion criteria mentioned in the study.\u0000Results: It has been found that sensorineural hearing loss (SNHL) was more common in diabetic patients group than controls group, 21% versus 8%. The prevalence of (SNHL) was more in male 31.7% than female diabetic patients 13.5%. Hearing threshold in diabetic patients was higher than that in control group. The hearing loss in diabetic patients is slowly progressive and directly related to the duration of diabetes.\u0000Conclusions: Sensorineural hearing loss has been found to be more common in diabetic patients than in control group, and the hearing loss in diabetic patients is slowly progressive. The hearing threshold in diabetic patients had a direct correlation with the duration of disease.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87876142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.36330/kmj.v19i1.12223
S. Almurshedi, R. Alasady
Background: Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, resulting in joint inflammation, pain, and limited mobility. The identification of novel biomarkers specific to RA could enhance early diagnosis and treatment and also improve the monitoring of the disease activity and treatment response. In this study, the levels of IL-22 were measured in 133 patients with inflammatory arthritis using the ELISA method with the aim of assessing the diagnostic value of IL-22 in the diagnosis of RA and evaluating the disease activity. The findings revealed that serum IL-22 levels were significantly higher in RA patients compared to patients with other types of inflammatory arthritis. Additionally, positive correlations were observed between IL-22 and disease activity scores as determined by CDAI, DAS-28 ESR, and DAS-28 CRP. Notably, when IL-22 was used as a diagnostic tool, with a cut-off value of ≥ 26.9 pg/ml, it exhibited a sensitivity of 83%, specificity of 75%, and an AUC of 0.838. Furthermore, significant associations were found between IL-22 levels and the age of RA patients, while no significant correlations were observed with gender, BMI, and smoking index. It is noteworthy that IL-22 levels were significantly correlated with ESR, RF titer, and ACPA levels. Consequently, IL-22 can be regarded as a valuable biomarker for diagnosing RA and evaluating disease activity. Subjects and method: This cross-sectional study was conducted from September 2022 to January 2023, involving 133 patients with inflammatory arthritis, including RA and other forms of inflammatory arthritis. All patients were recruited from As-Sader Teaching Hospital in Najaf. The ages of the patients included in the present study range from 20 to 70 years, with a sample comprising 116 females and 17 males. Results: The higher median (IQR) value of IL-22 was observed among the RA patients [36.9 (28.6-63.7) pg/ml] compared to that of the other patients with inflammatory arthritis [23.6 (19.8-26.8) pg/ml]. The difference between the two groups of patients was highly significant (P < 0.0001). Among the RA patients, a highly significant difference in the median (IQR) level of IL-22 was observed among the disease activity groups according to CDAI, DAS-28 ESR, and DAS-28 CRP (P < 0.0001). Conclusion: Interleukin-22 can be regarded as a reliable biomarker for the diagnosis of RA and holds potential for assessing disease activity.
{"title":"The Role of Interleukin-22 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis","authors":"S. Almurshedi, R. Alasady","doi":"10.36330/kmj.v19i1.12223","DOIUrl":"https://doi.org/10.36330/kmj.v19i1.12223","url":null,"abstract":"Background: Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, resulting in joint inflammation, pain, and limited mobility. The identification of novel biomarkers specific to RA could enhance early diagnosis and treatment and also improve the monitoring of the disease activity and treatment response. In this study, the levels of IL-22 were measured in 133 patients with inflammatory arthritis using the ELISA method with the aim of assessing the diagnostic value of IL-22 in the diagnosis of RA and evaluating the disease activity. The findings revealed that serum IL-22 levels were significantly higher in RA patients compared to patients with other types of inflammatory arthritis. Additionally, positive correlations were observed between IL-22 and disease activity scores as determined by CDAI, DAS-28 ESR, and DAS-28 CRP. Notably, when IL-22 was used as a diagnostic tool, with a cut-off value of ≥ 26.9 pg/ml, it exhibited a sensitivity of 83%, specificity of 75%, and an AUC of 0.838. Furthermore, significant associations were found between IL-22 levels and the age of RA patients, while no significant correlations were observed with gender, BMI, and smoking index. It is noteworthy that IL-22 levels were significantly correlated with ESR, RF titer, and ACPA levels. Consequently, IL-22 can be regarded as a valuable biomarker for diagnosing RA and evaluating disease activity. Subjects and method: This cross-sectional study was conducted from September 2022 to January 2023, involving 133 patients with inflammatory arthritis, including RA and other forms of inflammatory arthritis. All patients were recruited from As-Sader Teaching Hospital in Najaf. The ages of the patients included in the present study range from 20 to 70 years, with a sample comprising 116 females and 17 males. Results: The higher median (IQR) value of IL-22 was observed among the RA patients [36.9 (28.6-63.7) pg/ml] compared to that of the other patients with inflammatory arthritis [23.6 (19.8-26.8) pg/ml]. The difference between the two groups of patients was highly significant (P < 0.0001). Among the RA patients, a highly significant difference in the median (IQR) level of IL-22 was observed among the disease activity groups according to CDAI, DAS-28 ESR, and DAS-28 CRP (P < 0.0001). Conclusion: Interleukin-22 can be regarded as a reliable biomarker for the diagnosis of RA and holds potential for assessing disease activity.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88125412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.36330/kmj.v19i1.12014
Mohammed Hussein Abdulredha, Haydar Jawad Aljobouri, Mohammed Dhamin Alareedh
Background: Asthma and COPD remain poorly controlled diseases that significantly affect the quality of life of patients. Inhalers are the main therapeutic options. Poor inhaler technique is a major factor that leads to poor clinical consequences, affecting the effectiveness of treatment and further control of symptoms. Aim of the Study: the present study aims at evaluating the inhaler technique and its clinical consequence in COPD and asthma patients .Patients and Methods: This is a cross sectional study of 70 patients, 35 with COPD and 35 with Asthma, who are already on inhaler drugs in their treatment. The use of inhaler was evaluated by a checklist that contains seven steps of inhaler use; by asking the patients to use their inhalers as usual, the correct or incorrect steps were recorded. The result of each patient checklist was correlated with the patient demographic parameters and level of control of his disease (COPD or asthma) by using COPD assessment test (CAT) or asthma control test (ACT) respectively. The Results: A total of 70 patients were enrolled in this study; 35 had COPD and 35 were asthmatic. The COPD patients were significantly older than asthmatic, mean age was 65.5 ± 5.8 (range: 55 – 75) years and 36.4 ± 13.9 (range: 16 – 65) years, respectively. (P. value < 0.05). Males were dominant among COPD patients than asthmatic group; they contribute to 80% and 45.7%, respectively,(P. value < 0.05). The level of education was not significantly different between the groups (P > 0.05). Current smokers were significantly more frequent in COPD group than in asthmatic group, 40% vs. 14.3%, respectively. The duration of inhaler use was significantly longer in asthmatics than in the COPD group members; the mean duration of use was 5.2 ± 4.5 (range: 1 – 20) years in asthmatic compared to 2.4 ± 1.1 (range: 1 – 6) years in COPD group. Dry powder inhalers (DPI) were relatively more frequently used than metered dose inhalers (MDI) where DPI used by 51.4% and 54.3% in COPD and asthmatic group, respectively. The level of education of patients and longer duration of inhaler use correlate positively with good technique, while no significant correlation with other variables. Conclusion: A large proportion of the participants had a poor inhaler technique regardless of the type of disease and of inhaler (DPI or MDI). There was a positive correlation between proper use of inhaler and high educational level of patients and longer duration of use.
{"title":"Evaluation of Inhaler Technique In COPD And Asthma Patients","authors":"Mohammed Hussein Abdulredha, Haydar Jawad Aljobouri, Mohammed Dhamin Alareedh","doi":"10.36330/kmj.v19i1.12014","DOIUrl":"https://doi.org/10.36330/kmj.v19i1.12014","url":null,"abstract":"Background: Asthma and COPD remain poorly controlled diseases that significantly affect the quality of life of patients. Inhalers are the main therapeutic options. Poor inhaler technique is a major factor that leads to poor clinical consequences, affecting the effectiveness of treatment and further control of symptoms. Aim of the Study: the present study aims at evaluating the inhaler technique and its clinical consequence in COPD and asthma patients .Patients and Methods: This is a cross sectional study of 70 patients, 35 with COPD and 35 with Asthma, who are already on inhaler drugs in their treatment. The use of inhaler was evaluated by a checklist that contains seven steps of inhaler use; by asking the patients to use their inhalers as usual, the correct or incorrect steps were recorded. The result of each patient checklist was correlated with the patient demographic parameters and level of control of his disease (COPD or asthma) by using COPD assessment test (CAT) or asthma control test (ACT) respectively. The Results: A total of 70 patients were enrolled in this study; 35 had COPD and 35 were asthmatic. The COPD patients were significantly older than asthmatic, mean age was 65.5 ± 5.8 (range: 55 – 75) years and 36.4 ± 13.9 (range: 16 – 65) years, respectively. (P. value < 0.05). Males were dominant among COPD patients than asthmatic group; they contribute to 80% and 45.7%, respectively,(P. value < 0.05). The level of education was not significantly different between the groups (P > 0.05). Current smokers were significantly more frequent in COPD group than in asthmatic group, 40% vs. 14.3%, respectively. The duration of inhaler use was significantly longer in asthmatics than in the COPD group members; the mean duration of use was 5.2 ± 4.5 (range: 1 – 20) years in asthmatic compared to 2.4 ± 1.1 (range: 1 – 6) years in COPD group. Dry powder inhalers (DPI) were relatively more frequently used than metered dose inhalers (MDI) where DPI used by 51.4% and 54.3% in COPD and asthmatic group, respectively. The level of education of patients and longer duration of inhaler use correlate positively with good technique, while no significant correlation with other variables. Conclusion: A large proportion of the participants had a poor inhaler technique regardless of the type of disease and of inhaler (DPI or MDI). There was a positive correlation between proper use of inhaler and high educational level of patients and longer duration of use.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80592466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.36330/kmj.v19i1.12180
Ameer Mohammed Kadhim, Hawraa Ameer Mubark, Dhefaf Hameed Al-Mudhafar, Saif Jabbar Yasir
Background: Hepatitis B Virus (HBV) is a partly double-stranded, hepatotropic, non-cytotoxic Hepadnaviridae virus. HBV is linked to many autoimmune diseases, including Rheumatoid Arthritis(RA), Cryoglobulinemia, and Antiphospholipid Syndrome(APS). Anticardiolipin antibodies (ACL) are a type of anti-phospholipid antibodies(APA) that target cardiolipin molecules. They're more common in systemic lupus erythematosus (SLE) and APS. APA may be caused by viral infections such as HBV. Aim of the study: Determination of Anticardiolipin antibody positivity among hepatitis B virus-infected patients in Najaf governorate. material, and methods: a cross-sectional study was conducted between September 2022 to March 2023 in Najaf, a non-random sampling was depended, the sera of 113 HBV-infected patients were collected from the main health facilities in Najaf, and all had no other possible disease that is associated with APA, then it was tested for HBS antigen, total HBc antibodies, IgM HBc antibodies, ACL antibodies by ELISA technique. SPSS version 26 was used to perform the statistical analysis processes. Results: anti-cardiolipin antibodies(ACL) prevalence was 10.6%, The type of HBV infection and ACL production were significantly correlated (p<0.05), males had a higher percentage of ACL autoantibodies and middle age patients presented with the highest rate of ACL antibodies, however, there was no statistically significant relationship between ACL and age or gender. In Conclusion: hepatitis B virus (HBV) is one of the main viruses that lead to the production of ACL especially in middle-aged people males, the chronic type is more prevalent for ACL than the acute type.
背景:乙型肝炎病毒(HBV)是一种部分双链、嗜肝、无细胞毒性的肝病毒科病毒。HBV与许多自身免疫性疾病有关，包括类风湿关节炎(RA)、冷球蛋白血症和抗磷脂综合征(APS)。抗心磷脂抗体(ACL)是一种以心磷脂分子为靶点的抗磷脂抗体(APA)。它们在系统性红斑狼疮(SLE)和APS中更常见。APA可能由HBV等病毒感染引起。研究目的:测定纳杰夫省乙型肝炎病毒感染患者的抗心磷脂抗体阳性。材料和方法:于2022年9月至2023年3月在纳杰夫进行横断面研究，采用非随机抽样，从纳杰夫主要卫生机构收集113例hbv感染患者的血清，所有患者均无其他可能与APA相关的疾病，然后采用ELISA技术检测HBS抗原、总HBc抗体、IgM HBc抗体、ACL抗体。采用SPSS version 26进行统计分析处理。结果:抗心磷脂抗体(anti-cardiolipin antibodies, ACL)患病率为10.6%，HBV感染类型与ACL的产生有显著相关(p<0.05)，男性自身抗体比例较高，中年患者的ACL抗体比例最高，但ACL与年龄和性别之间无统计学意义的关系。结论:乙型肝炎病毒(HBV)是导致ACL产生的主要病毒之一，特别是在中年男性中，慢性型比急性型更常见。
{"title":"The Impact Of Hepatitis B Infection On The Development Of Anti-Cardiolipin Antibodies In Najaf Province","authors":"Ameer Mohammed Kadhim, Hawraa Ameer Mubark, Dhefaf Hameed Al-Mudhafar, Saif Jabbar Yasir","doi":"10.36330/kmj.v19i1.12180","DOIUrl":"https://doi.org/10.36330/kmj.v19i1.12180","url":null,"abstract":"Background: Hepatitis B Virus (HBV) is a partly double-stranded, hepatotropic, non-cytotoxic Hepadnaviridae virus. HBV is linked to many autoimmune diseases, including Rheumatoid Arthritis(RA), Cryoglobulinemia, and Antiphospholipid Syndrome(APS). Anticardiolipin antibodies (ACL) are a type of anti-phospholipid antibodies(APA) that target cardiolipin molecules. They're more common in systemic lupus erythematosus (SLE) and APS. APA may be caused by viral infections such as HBV. Aim of the study: Determination of Anticardiolipin antibody positivity among hepatitis B virus-infected patients in Najaf governorate. material, and methods: a cross-sectional study was conducted between September 2022 to March 2023 in Najaf, a non-random sampling was depended, the sera of 113 HBV-infected patients were collected from the main health facilities in Najaf, and all had no other possible disease that is associated with APA, then it was tested for HBS antigen, total HBc antibodies, IgM HBc antibodies, ACL antibodies by ELISA technique. SPSS version 26 was used to perform the statistical analysis processes. Results: anti-cardiolipin antibodies(ACL) prevalence was 10.6%, The type of HBV infection and ACL production were significantly correlated (p<0.05), males had a higher percentage of ACL autoantibodies and middle age patients presented with the highest rate of ACL antibodies, however, there was no statistically significant relationship between ACL and age or gender. In Conclusion: hepatitis B virus (HBV) is one of the main viruses that lead to the production of ACL especially in middle-aged people males, the chronic type is more prevalent for ACL than the acute type.","PeriodicalId":17869,"journal":{"name":"Kufa Journal For Veterinary Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80755505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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