Physiological Significance of TRPV4 Channels in Non-Myelinating Schwann cells

Xiaona Feng, Xuejun Song, M. Tominaga
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Abstract

Schwann cells (SCs) are specialized glial cells that wrap and protect axons in the peripheral nervous system (PNS). There are a variety of SCs including non-myelinating SCs such as Remak SCs, perisynaptic/ terminal SCs, repair/ Bunger SCs and nociceptive SCs that surround axons or axon terminals without forming myelin sheath. Non-myelinating SCs play important roles in proper myelin development and maintenance, repair and regeneration after injury, and nociception. A recently published work showed that transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable permeable cation channel, is exclusively expressed in non-myelinating SCs rather than myelinating SCs and plays an important role in nerve demyelination in response to injury. In this short communication, we are going to review the recent studies and discuss the possible significance of TRPV4 channels in the non-myelinating SCs.
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TRPV4通道在非髓鞘雪旺细胞中的生理意义
雪旺细胞(SCs)是外周神经系统中包裹和保护轴突的特化胶质细胞。有各种各样的SCs,包括非髓鞘SCs,如Remak sc,周围突触/末端sc,修复/饥饿sc和伤害性sc,它们环绕轴突或轴突末端而不形成髓鞘。非髓鞘SCs在髓鞘发育和维持、损伤后修复和再生以及伤害感受中发挥重要作用。最近发表的一项研究表明,瞬时受体电位香草样蛋白4 (TRPV4)是一种Ca2+渗透性阳离子通道,仅在非髓鞘性SCs中表达,而不是在髓鞘性SCs中表达,并在神经损伤脱髓鞘反应中起重要作用。在这篇简短的文章中,我们将回顾最近的研究,并讨论TRPV4通道在非髓鞘SCs中的可能意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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