Mitochondrial Number in Oligo and Azoospermia Male Patients

Abstract

Male infertility causes present in about 50% of the infertility cases, the standard quantity and quality of semen ejaculated during each coitus averages about 2-4 milliliters and every milliliter of seminal fluid contains contain about 100-120 million sperm/ ml. When the number of sperm in each milliliter drops below 20 million; the person is probably having infertile problem. Forty-five semen samples were collected from males with ages ranged from 25 to 45 years. The samples were divided into three groups each consists of 15 males. The first group represent control group included 15 apparently health fertile subject. The second group contain 15 patients with oligospermia with sperm count ≤20 million sperm / ml. The results of this table display there were significant variation in count between control group (54 ± 19.7) in comparison to oligo group (9.2 ± 7.49) and the p ≤0.000. there is a significant variation in active motility between control group (37.6 ± 15.1) in comparison to oligo group (18.0 ± 10.1), we can note a variation in normal morphology between control group (69.2 ± 8.0) and oligo group (60 ± 9.6) but it is less than the variation between count and the active motility as we mentioned above, whereas the p-value≤ (0.01). There was significant reduction in both seminal pyruvate and Lactate in Azoospermia patients in comparison to control group p<0.01 figure 1 and 2 respectively. In conclusion; Mitochondrial copy number significantly related to fertility status in males