P. Upadhya, K. L. Nguyen, Yaochun Shen, J. Obradovic, K. Fukushige, R. Griffiths, L. Gladden, A. Davies, E. Linfield
{"title":"Transformation-induced evolution of far-infrared vibrational modes in theophylline","authors":"P. Upadhya, K. L. Nguyen, Yaochun Shen, J. Obradovic, K. Fukushige, R. Griffiths, L. Gladden, A. Davies, E. Linfield","doi":"10.1109/ICIMW.2004.1422145","DOIUrl":null,"url":null,"abstract":"Time-resolved terahertz (THz) spectroscopy has been used to characterize polymorphic transformations in crystalline theophylline, a widely used pharmaceutical compound. On transformation, different inter-molecular bonding arrangements arise, leading to distinct THz spectral signals. Changes between polymorphic forms were confirmed by IR and powder X-ray diffraction measurements.","PeriodicalId":13627,"journal":{"name":"Infrared and Millimeter Waves, Conference Digest of the 2004 Joint 29th International Conference on 2004 and 12th International Conference on Terahertz Electronics, 2004.","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infrared and Millimeter Waves, Conference Digest of the 2004 Joint 29th International Conference on 2004 and 12th International Conference on Terahertz Electronics, 2004.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICIMW.2004.1422145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Time-resolved terahertz (THz) spectroscopy has been used to characterize polymorphic transformations in crystalline theophylline, a widely used pharmaceutical compound. On transformation, different inter-molecular bonding arrangements arise, leading to distinct THz spectral signals. Changes between polymorphic forms were confirmed by IR and powder X-ray diffraction measurements.