Modification of nonwoven fabrics with chlorhexidine to impart antibacterial properties

M. Lisanevich, E. Perushkina
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Abstract

This paper addresses the possibility of modifying the Holofiber® nonwoven fabrics with a 0.05% solution of chlorhexidine bigluconate in order to impart antimicrobial properties, since these materials are planned for medical use, in particular wound dressings. One stage in the development of a wound dressing based on nonwoven Holofiber® involved its impregnation with chlorhexidine by spraying a solution using a spray gun; the solution accumulated on the surface of the nonwoven fabrics in the form of drops. The agent was applied on both sides of samples having dimensions of 210×297 mm. Samples following impregnation were dried to a constant weight. The drying time of Holofiber® VOLUMETRIC P 84 amounted to 10 min. The antibacterial properties of modified nonwoven fabrics were evaluated by the following methods: modified disc diffusion (DDM) method, measurement of antibacterial activity on the surface of plastics and other non-porous materials, ISO-22196. The inhibition zone of Staphylococcus aureus bacteria for Holofiber® nonwoven fabrics treated with 0.05% chlorhexidine bigluconate solution amounted to 17 mm, which indicates the bactericidal properties of the studied material. In addition, it was confirmed by a decrease in the number of bacteria following the 24-hour incubation of a test microorganism in the presence of a polymer. The percentage of Staphylococcus aureus cell death equalled 99%. These results indicate that the nonwoven Holofiber® fabrics can be treated with a solution of chlorhexidine bigluconate 0.05% to impart antibacterial properties, since the substance used for treating a sample remains in the material following drying and exhibits an antibacterial effect.
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氯己定改性非织造布的抗菌性能
本文探讨了用0.05%的双糖酸氯己定溶液修饰Holofiber®非织造布的可能性,以赋予其抗菌性能,因为这些材料计划用于医疗用途,特别是伤口敷料。基于无纺布Holofiber®的伤口敷料开发的一个阶段是用喷枪喷洒溶液,用氯己定浸渍;溶液以水滴的形式积聚在非织造布表面。该剂应用于尺寸为210×297 mm的样品的两侧。浸渍后的样品被干燥至定重。Holofiber®VOLUMETRIC p84干燥时间为10 min。通过以下方法评估改性无纺布的抗菌性能:改性圆盘扩散(DDM)法,塑料和其他无孔材料表面抗菌活性测定,ISO-22196。0.05%双葡酸氯己定溶液处理后的Holofiber®无纺布对金黄色葡萄球菌的抑制带为17 mm,表明了所研究材料的杀菌性能。此外,在聚合物存在下对测试微生物进行24小时孵育后,细菌数量减少证实了这一点。金黄色葡萄球菌细胞死亡率为99%。这些结果表明,无纺布Holofiber®织物可以用0.05%的双葡酸氯己定溶液处理,以赋予抗菌性能,因为用于处理样品的物质在干燥后仍留在材料中,并表现出抗菌效果。
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