A Practical Example on Uncertainty Evaluation: Spectrophotometric Determination of pK a

E. J. Díaz-Montaña, Á. Alcázar, J. Jurado, F. Pablos
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引用次数: 1

Abstract

As it can be read in EURACHEM/CITAC Guide for quantifying uncertainty in analytical measurements [1], many important decisions are based on the results of chemical quantitative analysis and, for this reason, is very important to ensure the quality of analytical methods. Nowadays, there has been a great emphasis on the precision of results obtained using a specified analytical method and in establishing their traceability to a defined standard. For this aim, internal quality control procedures, proficiency testing an accreditation have become very useful tools. Chemists are being asked to demonstrate the quality of their results, including their agreement with others results, being measurement uncertainty one useful measure of this. As a consequence of these requirements, our students are expected to be able to apply measurement uncertainty evaluation and propagation. In this work, we propose a training practical example that can be used by people learning about the evaluation of uncertainty in measurements and its propagation in different cases. The chosen example is the photometric determination of the ionization constant of acetaminophen by measuring the absorbance of an acetaminophen solution at different pH values. According to Hildebrand and Reilley method [2], the next relation can be established:
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不确定度评定的实例:分光光度法测定钾
正如《EURACHEM/CITAC分析测量不确定度量化指南》[1]中所述,许多重要决策都是基于化学定量分析的结果,因此对保证分析方法的质量非常重要。如今,人们非常强调使用特定分析方法获得的结果的准确性,并建立其可追溯性,以确定标准。为此,内部质量控制程序、能力测试和认证已成为非常有用的工具。化学家被要求证明他们的结果的质量,包括他们与其他结果的一致性,测量不确定度是一个有用的测量方法。由于这些要求,我们的学生被期望能够应用测量不确定度评估和传播。在这项工作中,我们提出了一个训练实例,可以用于人们学习测量不确定度的评估及其在不同情况下的传播。所选的例子是通过测量对乙酰氨基酚溶液在不同pH值下的吸光度来测定对乙酰氨基酚的电离常数。根据Hildebrand和Reilley方法[2],可以建立下一个关系式:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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