Antibacterial evaluation of Some Synthesis Complexes of Azo-dye Ligands.

Abstract

In present work, two ligands, azo Schiff-base (AZD1 and AZD2), were synthesized by twosteps. Firstly, Schiff-bases were prepared by condensation of Salicyldehyde with anthranilic acid, followed by diazotization of aromatic amines and their subsequent coupling reaction with Schiff-bases. Consequently, 8 complexes of the type [M(AZD1)Cl2] and [M(AZD2)Cl2], where M = Cu(II), Ni(II), Co(II), Mn(II); were synthesized and characterized with the help of molarconductance, magnetic susceptibility measurements, FT-IR, micro elemental analysis , H1 NMR,and Uv–visible spectroscopy. The spectral data revealed that the ligands act as bidentate ligand,the hydroxyl of carboxylic group and the azo group in AZD1 and hydroxyl of phenyl group andthe azomethin group in AZD2 ligand are co-ordination to the central metal atoms. Lastly, all thecompounds were screened for their antibacterial activity, using well-diffusion method. Inconclusion, the ligands and some of the complexes exhibited appreciable antibacterial activityagainst Escherichia coli Klebsiella pneumonia and Staphylococcus haemolyticus andStaphylococcus aurous.