Elsayed A. Aboutabl , Aida A. El-Azzouny , Manal S. Afifi
{"title":"PMR assay of vincamine and formulations","authors":"Elsayed A. Aboutabl , Aida A. El-Azzouny , Manal S. Afifi","doi":"10.1016/S0031-6865(98)00022-3","DOIUrl":null,"url":null,"abstract":"<div><p><span>An accurate and specific PMR method for the determination of vincamine in the bulk drug, as well as solid and liquid dosage forms has been developed. The determination is based on the integration of the three methyl protons of the CH</span><sub>2</sub>–CH<sub>3</sub><span> group of vincamine, relative to that of the two noncarboxylic protons of maleic acid (internal standard). The method furnishes a specific means of identification of vincamine as well as the simultaneous detection of the possible presence of other alkaloids.</span></p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 4","pages":"Pages 193-197"},"PeriodicalIF":0.0000,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00022-3","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
An accurate and specific PMR method for the determination of vincamine in the bulk drug, as well as solid and liquid dosage forms has been developed. The determination is based on the integration of the three methyl protons of the CH2–CH3 group of vincamine, relative to that of the two noncarboxylic protons of maleic acid (internal standard). The method furnishes a specific means of identification of vincamine as well as the simultaneous detection of the possible presence of other alkaloids.
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