Study of Antimicrobial Activity of Some Synthesized Pyrimidine-Triazole Derivatives

Abstract

Some novel derivatives of 2,2′-(4,4′-(((4-(3-oxomorpholino)phenyl)-azanediyl)-bis(methylene))bis(1H- 1,2,3-triazole-4,1-diyl))bis(N-(4-phenyl-pyrimidin-2-yl)acetamide) have been synthesized from 4-(4- aminophenyl)morpholin-3-one molecule by multistep process. The structures of all the synthesized compounds were established by different spectroscopic techniques such as 1H NMR, infrared and mass. The antimicrobial activity of these pyrimidine-triazole derivatives were also investigated against selected bacterial and fungal strains in two different organic solvents (N,N-dimethyl formamide and dimethyl sulphoxide).