Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats

Abstract

The present study aims to evaluate the possible protective role of polysaccharides extracted from the Egyptian mango Mangifera indica L. (MPS) and silymarin against cyclophosphamide (CP) nephrotoxicity in male albino rats. Male rats were randomly divided into, control group (administered distilled water orally for 10 days) and MPS (500, 1000 mg/kg, p.o.) and/or silymarin (150 mg/kg, p.o.) treated groups for 10 days. In the last 5 days of treatment rats were administered CP (150 mg/kg, i.p). The MPS revealed significant prophylactic effect against kidney injury induced by CP as demonstrated by enhancement of the kidney function via decreasing serum creatinine, urea and uric acid. Treatment of rats with MPS extract and/or silymarin significantly increased the level of reduced glutathione (GSH) and superoxide dismutase (SOD) activity while decreased the level of total malondialdehyde (MDA) and glutathione-S-transferase (GST). Also, histopathological examinations confirmed the protective efficacy of MPS and/or silymarin against CP nephrotoxicity. In conclusion, the obtained results of the present study support the protective antioxidant role of MPS and/or silymarin against CP-induced kidney disorder in rats.