Energy Efficient Synthesis of various Benzodiazepin-2-ones using Microwave Synthesizer

Abstract

Benzodiazepine-2-one moiety consists of a seven-membered heterocyclic ring, a derivative of benzodiazepine group, that works in the central nervous system and used for a variety of medical conditions, such as anxiety, seizures and alcohol withdrawal. Microwave assisted synthesis of certain medically important benzodiazepin-2-ones was carried out using hexamine and ammonium chloride starting from 2-aminobenzophenones. Feasibility and optimization of the reaction conditions under closed vessel CEM microwave synthesizer provide the desired product with excellent yields (~90%), within minutes of focused microwave irradiation, without the use of catalyst, thereby, revealing the benefit of saving energy and time.