Dendrosomal nano-curcumin; The novel formulation to improve the anticancer properties of curcumin

M. Birgani, Vahid Erfani-Moghadam, E. Babaei, F. Najafi, M. Zamani, Molood Shariati, Shima Nazem, Baharak Farhangi, P. Motahari, M. Sadeghizadeh
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引用次数: 35

Abstract

Curcumin is a hydrophobic polyphenol extracted from the plant curcuma longa with establishedanticancer properties. However, curcumin benefits have been impaired by its very low watersolubility, low absorption, rapid metabolism and clearance from the body. Recently,nanotechnology promises to be helpful in development of drugs delivery systems by recentadvances in macromolecular design of nanocarriers. In this review, we present the novelgeneration of nano-vehicles termed dendrosomes which are readily synthesized fromesterification of oleic acid and polyethylene glycol residues. Dendrosomes efficientlyencapsulate curcumin in a spherical micellar or polymersome structures which leads to increaseaqueous solubility of this hydrophobic agent and higher bioavailability of curcumin. Anticancerpotency of this nanoformulation was confirmed in different mouse and human cancercells including fibrosarcoma, colon, glioblastoma, bladder, gastric, breast and hepatocellularcarcinoma in vitro and vivo. It has also demonstrated that this nano preparation has nocytotoxicity effects on normal cells. Finally, these results introduce dendrosomal curcumin aspotent anti-tumor agent although further clinical examinations are needed.
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Dendrosomal nano-curcumin;新配方提高了姜黄素的抗癌性能
姜黄素是从姜黄植物中提取的疏水多酚,具有公认的抗癌特性。然而,姜黄素的益处因其极低的水溶性、低吸收、快速代谢和从体内清除而受到损害。近年来,随着纳米载体大分子设计的进展,纳米技术有望在药物递送系统的开发中发挥重要作用。在这篇综述中,我们介绍了新一代的纳米载体,称为树突体,它很容易从油酸和聚乙二醇残留物的酯化反应中合成。树突体有效地将姜黄素包裹在球状胶束或聚合体结构中,从而增加了这种疏水剂的水溶性,提高了姜黄素的生物利用度。该纳米制剂在体外和体内对纤维肉瘤、结肠癌、胶质母细胞瘤、膀胱癌、胃癌、乳腺癌和肝癌等不同的小鼠和人肿瘤细胞均有抗癌作用。研究还表明,该纳米制剂对正常细胞无细胞毒性作用。最后,这些结果表明,尽管需要进一步的临床检查,但树状体姜黄素是一种有效的抗肿瘤药物。
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