Effect of Food on Bioavailability of Drug through Gastro-Retentive Drug Delivery System

Abstract

Gastro retentive drug delivery systems (GRDDS) have been explored for controlling the release of the drugs by oral administration. However, since these systems are intended to reside in the gastric region for longer period of time, several factors are expected to hamper the absorption rates of the drug in GRDDS. These systems are in contact with the gastric content for longer time and thus, “Food” is expected to interfere with the rate of absorption from these systems. This article focuses on various foods related factors responsible for affecting absorption from the GRDDS type of novel system.