How oxidative stress contributes to neurodegenerative diseases

Abstract

BRAIN HEALTH AND ENERGY SUPPLY To guarantee a continuous supply of energy to neurones and the removal of dangerous chemical waste, the human body has evolved complex networks of hugely cooperative mechanisms. Specialised non-nerve cells, known as glial cells, constantly interact with the surface of the neurone. They provide nutrients, remove waste and toxins, and regulate the chemical environment of the brain. When any of these functions fail to support neurone activity, their structural integrity is compromised and ability to communicate with each other reduced. This can lead to neuronal death, and reduction in the overall connectivity between neurones, as most neurones in the brain cannot regenerate.