Synthesis of New Azo Compounds and Their Application for a Simple Spectrophotometric Determination of Methyldopa Drug Using Anthranilic Acid and 2-Aminopyrimidine as Reagents

Ekhlas ABD ALKAREEM, Nuha FARHAN ABD AL-KARİM, Israa I Mahmoud
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Abstract

The goal of the current work is to synthesize methyldopa derivatives. Based on these reactions, two easy, speedy, accurate, inexpensive, and sensitive spectrophotometric approaches have been established for determining methyldopa (MED) in both pure and pharmaceutical forms. The proposed azo-coupling method depends on forming an azo compound between methyldopa drug and 2-AMPY or ANTH to produce two compounds of MED-2AMPY and MED-ANTH in the alkaline medium. The characterization of synthesized compounds utilizing UV-Visible and FT-IR spectra. FT-IR spectra of 2AMPY-MED confirm the existence of OH, C-Hor, C-Hal, NH, N=N, C=O, and C=C vibration at 3455, 3059, 2973, 3100, 1476,1692, and 1560 cm-1, and FT-IR spectra of ANTH-MED confirm the existence of OH, C-Hor, NH, C=O and N=N vibration at 3490, 3050, 3100, 1701 and 1462 cm-1, correspondingly. The obtained color of azo compounds is spectrophotometrically measured for the previously mentioned azo compounds at 450 and 455 nm, respectively. Under perfect conditions, the azo compound solutions exhibited molar absorptivities of 1563.0058 and 2091.0285 L.mol-1.cm-1, Sandell's sensitivity of 0.135 and 0.10 µg.cm-1, and Beer-Lambert's law are obeyed over the ranges 6.25- 62.5 mg. L-1 for the two developed procedures, respectively.
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新型偶氮化合物的合成及其在以邻氨基苯甲酸和2-氨基嘧啶为试剂分光光度法测定甲基多巴药物中的应用
本研究的目的是合成甲基多巴衍生物。基于这些反应,建立了两种简便、快速、准确、廉价、灵敏的分光光度法测定纯甲基多巴和药物甲基多巴。本文提出的偶氮偶联方法是在甲基多巴药物与2-AMPY或ANTH之间形成偶氮化合物,在碱性介质中产生MED-2AMPY和MED-ANTH两种化合物。利用紫外可见光谱和红外光谱对合成化合物进行表征。2AMPY-MED的FT-IR光谱证实了3455、3059、2973、3100、1476、1692和1560 cm-1处OH、C- hor、C- hal、NH、N=N、C=O和C=C振动的存在,ANTH-MED的FT-IR光谱分别证实了3490、3050、3100、1701和1462 cm-1处OH、C- hor、NH、C=O和N=N振动的存在。所得到的偶氮化合物的颜色分别在450和455nm处用分光光度法测量。在理想条件下,偶氮化合物溶液的摩尔吸收率分别为1563.0058和2091.0285 l mol-1。cm-1, Sandell灵敏度为0.135和0.10µg。在6.25- 62.5 mg范围内,均符合比尔-朗伯定律。L-1分别为两个开发的程序。
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