Catherine Astarie-Dequeker, J. Nigou, C. Passemar, C. Guilhot
{"title":"The role of mycobacterial lipids in host pathogenesis","authors":"Catherine Astarie-Dequeker, J. Nigou, C. Passemar, C. Guilhot","doi":"10.1016/j.ddmec.2010.09.003","DOIUrl":null,"url":null,"abstract":"<div><p><span>Several mycobacteria are remarkably successful human pathogens that cause wellknown infections such as tuberculosis and leprosy or emerging diseases such as </span><span><em>Buruli ulcer</em></span><span><span>. On encountering the virulent mycobacteria, the host develops a strong immune response which is dedicated to combat the invasion while bacilli have evolved several strategies to counteract and adapt to this hostile environment. Being positioned at the bacterial surface, mycobacterial </span>lipids contribute to the interplay between host and pathogen. This review will briefly discuss some unusual mycobacterial lipids that have been identified, focusing on their immunomodulatory properties.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e33-e41"},"PeriodicalIF":0.0000,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.003","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18
Abstract
Several mycobacteria are remarkably successful human pathogens that cause wellknown infections such as tuberculosis and leprosy or emerging diseases such as Buruli ulcer. On encountering the virulent mycobacteria, the host develops a strong immune response which is dedicated to combat the invasion while bacilli have evolved several strategies to counteract and adapt to this hostile environment. Being positioned at the bacterial surface, mycobacterial lipids contribute to the interplay between host and pathogen. This review will briefly discuss some unusual mycobacterial lipids that have been identified, focusing on their immunomodulatory properties.
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