Risk factors analysis of hyperthyroidism complicated hyperthyroid heart disease

Q3 Medicine 中华地方病学杂志 Pub Date : 2011-03-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2011.02.030

Chong Guan-feng, G. Jie, M. Yuqin, Liang Huaju, Zhang Xia, Luo Xiao-hong, Xiang You-zhang

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Abstract

Objective To study the risk factors of hyperthyroid heart diseases(HHD) by analyzing clinical features of patients in order to provide a scientific basis for prevention and treatment of HHD. Methods Nine hundred and eighty two cases were selected as objective from in-patient data of Thyroid Disease Treatment Centre of Shandong Province. The cases were divided into hyperthyroidism group and HHD group. The variables of etiology,sex, age, duration of disease, TSH, FT3, FT4 and TRAb were analyzed by comparative analysis. The risk factors were analyzed by logistic regression. Results The prevalence of hyperthyroidism complicated hyperthyroid heart disease was 7.7%(76/982), age, duration of diseases, FT3, TRAb in the HHD group were [(51.4 ± 11.5), (6.3 ±2.1) years, 21.6 pmol/L, 71.6 U/L], in hyperthyroidism group were [(37.9 ± 9.8), (2.6 ± 1.3) years, 14.9pmol/L, 49.6 U/L]. The differences were statistically significant(u = 9.93,15.23, T = 44954,48792.5, P ＜ 0.05)between the two groups. The factors of the older, higher FT3 and TRAb, longer duration, Graves disease (OR =1.751,1.470,1.483,1.445,1.234) increased the risk of HHD. Conclusions Graves disease, longer duration, old age, higher FT3 and TRAb are the risk factors of HHD. Timely prevention and control of risk factors is necessary to reduce the incidence of HHD. Key words: Hyperthyroidism; Heart diseases; Risk factor

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甲亢合并甲亢性心脏病的危险因素分析

目的通过分析甲亢性心脏病(HHD)患者的临床特点，探讨其危险因素，为预防和治疗HHD提供科学依据。方法选取山东省甲状腺疾病诊疗中心住院病例982例作为研究对象。患者分为甲亢组和HHD组。比较分析病因、性别、年龄、病程、TSH、FT3、FT4、TRAb等变量。采用logistic回归分析危险因素。结果甲亢合并甲亢性心脏病患病率为7.7%(76/982)，HHD组年龄、病程、FT3、TRAb分别为(51.4±11.5)年、(6.3±2.1)年、21.6 pmol/L、71.6 U/L，甲亢组分别为(37.9±9.8)年、(2.6±1.3)年、14.9pmol/L、49.6 U/L。两组间差异均有统计学意义(u = 9.93,15.23, T = 44954,48792.5, P < 0.05)。年龄较大、FT3和TRAb较高、病程较长、Graves病(OR =1.751、1.470、1.483、1.445、1.234)增加HHD发生风险的因素。结论Graves病、病程长、年龄大、FT3和TRAb增高是HHD的危险因素。及时预防和控制危险因素是降低HHD发病率的必要条件。关键词:甲亢;心脏疾病;风险因素

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.