Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome

Bastomy Eka Rezkita, Ina Agustin Pertiwi, Ismi Cahya Dhelima, D. R. Budiani, Steven Irving
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Abstract

Background: Metabolic syndrome has been associated with chronic inflammation due to the increase of lymphocyte focus on hepatic lobular tissue. Moringa oleifera Lam. is an herbal plant that potentially reduce the inflammation process. This study aims to evaluate the effect of Moringa seed extract (MSE) on hepatic lobularinflammation in rats with hepatic tissue metabolic syndrome (MetS).Method: Twenty-four male Wistar rats (n = 24) were assigned into four groups: one control group (C) and three MetS groups, fed with a high-fat, high-fructose diet (HFHFD) daily for 53 days. After 53 days, respectively, MetS 2 and MetS 3 groups were given 150 and 200 mg/kg MSE. After 28 days of MSE administration, the rats were sacrificed, and then hepatic lobular inflammation measured with lobular inflammation score. The effect of MSE on hepatic lobular inflammation was analyzed with Kruskal-Wallis and Mann-Whitney test.Results: There was a significant difference in hepatic lobular inflammation between four groups (p = 0.000). Mann-Whitney showed a significant difference between C vs. MetS 1, MetS 1 vs. MetS 2, and MetS 1 vs. MetS 3 (p = 0.000), but not significant C vs. MetS 2 (p = 0.364), C vs. MetS 3 (p = 0.109), MetS 2 vs. MetS 3 (p = 0.533).Conclusion: MSE at the dose of 150 mg/kg and 200 mg/kg significantly reduces lobular inflammation in hepatic tissue of MetS rats.
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辣木的保肝作用。种子提取物对代谢综合征大鼠肝脏炎症的影响
背景:代谢综合征与慢性炎症有关,因为肝小叶组织的淋巴细胞集中增加。辣木。是一种草本植物,可以潜在地减少炎症过程。本研究旨在探讨辣木籽提取物(MSE)对肝组织代谢综合征(MetS)大鼠肝小叶炎症的影响。方法:24只雄性Wistar大鼠(n = 24)分为4组:1个对照组(C)和3个MetS组,每天饲喂高脂高果糖饲料(HFHFD),连续饲喂53 d。53 d后,MetS 2组和MetS 3组分别给予150和200 mg/kg MSE。给药28 d后处死大鼠,用肝小叶炎症评分法测定肝小叶炎症程度。采用Kruskal-Wallis和Mann-Whitney试验分析MSE对肝小叶炎症的影响。结果:四组大鼠肝小叶炎症程度差异有统计学意义(p = 0.000)。Mann-Whitney显示了C与MetS 1、MetS 1与MetS 2、MetS 1与MetS 3之间的显著差异(p = 0.000),但C与MetS 2 (p = 0.364)、C与MetS 3 (p = 0.109)、MetS 2与MetS 3 (p = 0.533)之间的不显著差异。结论:150 mg/kg和200 mg/kg剂量的MSE可显著减轻MetS大鼠肝组织小叶炎症。
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审稿时长
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