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Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia 天冬酰胺酶诱导的急性坏死性胰腺炎导致急性淋巴细胞白血病成人慢性胰腺炎和假性囊肿
Pub Date : 2023-04-10 DOI: 10.24871/241202398-101
R. Adiwinata, B. J. Waleleng, H. Haroen, Linda Rotty, Fandy Gosal, Luciana Rotty, Cecillia Hendratta, P. Lasut, Jeanne Winarta, Andrew Waleleng, M. Tendean
L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 
天冬酰胺酶是急性淋巴细胞白血病(ALL)治疗的主要化疗方案之一。急性胰腺炎是l-天冬酰胺酶治疗的严重副作用之一,可能导致化疗周期中断。假性囊肿和慢性胰腺炎的长期并发症可能是毁灭性的。天冬酰胺酶引起的胰腺炎在成人中是罕见的,因为ALL的性质通常发生在儿童人群中。天冬酰胺酶诱发胰腺炎的病理生理机制尚不清楚。我们报告一位18岁男性急性急性胰腺炎合并天冬酰胺酶诱发急性坏死性胰腺炎并发慢性胰腺炎和假性囊肿。
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引用次数: 0
The Plausible Use of Mango (Mangifera indica) Peel Isoquercitrin as Adjuvant Therapy for Colorectal Cancer: Translating Research from Bench to Bedside 芒果(Mangifera indica)皮异槲皮素作为结直肠癌辅助治疗的可行性研究:从实验到临床的转化研究
Muhammad Habiburrahman, Stefanus Sutopo, Nur Rahadiani
A deadly and debilitating disease, colorectal cancer (CRC), is rapidly becoming a significant threat to public health. However, current therapeutic approaches are still hampered by various side effects. Due to its benefits and remarkable apoptotic impact on cancer cells, plant-derived flavonoids now garner interest as candidates for cancer therapy. Isoquercitrin, a flavonoid commonly found in fruit plants, especially mangoes, is notable due to its ability to inhibit cancer development through various mechanisms. This review aims to highlight the use of isoquercitrin extracted from mango peels in inhibiting CRC carcinogenesis. A literature search was done on Pubmed, Proquest, and Google Scholar using inclusion and exclusion criteria, and a narrative review was synthesised using the evidence gathered. Validity assessment was done through the the Office of Health Assessment and Translation (OHAT) and Oxford Center for Evidence-Based Medicine (CEBM) critical assessment tools. Evidence suggested that isoquercitrin is promising as adjuvant therapy in CRC. It may inhibit overaccumulation of cytoplasmic β-catenin and its translocation into the nucleus, thus downregulating the expression of target proto-oncogenes leading to carcinogenesis of colon crypts. Isoquercitrin concentration in mango peel is abundant, 557.7 mg/kg in dried mango peel and 31.0 mg/kg in pure extracts. A pharmacology study approved that a daily intake of 5.4 mg/kgBW of isoquercitrin has an effective anticancer effect. This substance has good oral bioavailability and is well-tolerated but inhibits the metabolising enzymes CYP1A1 and CYP1B1. In conclusion, isoquercitrin is a potential adjuvant in inhibiting CRC growth with minimum costs and side effects.
结直肠癌(CRC)是一种致命且使人衰弱的疾病,正迅速成为对公众健康的重大威胁。然而,目前的治疗方法仍然受到各种副作用的阻碍。由于其对癌细胞的益处和显著的凋亡影响,植物衍生的黄酮类化合物现在作为癌症治疗的候选者引起了人们的兴趣。异槲皮苷是一种常见于水果植物,尤其是芒果中的类黄酮,因其通过各种机制抑制癌症发展的能力而备受关注。本文综述了从芒果皮中提取的异槲皮素在抑制结直肠癌癌变中的应用。使用纳入和排除标准在Pubmed、Proquest和Google Scholar上进行文献检索,并使用收集到的证据合成一篇叙述性综述。效度评估是通过健康评估和翻译办公室(OHAT)和牛津循证医学中心(CEBM)的关键评估工具进行的。有证据表明异槲皮素有希望作为结直肠癌的辅助治疗。它可能抑制细胞质β-catenin的过度积累及其向细胞核的易位,从而下调靶原癌基因的表达,导致结肠隐窝的癌变。芒果皮中异槲皮素含量丰富,干芒果皮中异槲皮素含量为557.7 mg/kg,纯芒果皮中异槲皮素含量为31.0 mg/kg。一项药理学研究证实,每天摄入5.4毫克/千公斤重的异槲皮素具有有效的抗癌作用。该物质具有良好的口服生物利用度和良好的耐受性,但抑制代谢酶CYP1A1和CYP1B1。综上所述,异槲皮苷是一种潜在的抑制结直肠癌生长的佐剂,其成本和副作用最小。
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引用次数: 0
Association between Food Specific IgG Antibodies with Clinical Activity of Disease in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study 食物特异性IgG抗体与炎症性肠病患者疾病临床活动性之间的关系:一项横断面研究
Santi Sumihar Rumondang Parhusip, I. Rengganis, M. Simadibrata, M. Abdullah, H. Shatri, E. Yunihastuti, Heri Wibowo
Background: Inflammatory bowel disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile.Method: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo index and Crohn's disease activity index.Results: The highest proportion of dietary IgG in Crohn's disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347; p = 0.041) and chickpeas IgG (r = -0.473; p = 0.017) with clinical disease activity; while in Crohn's disease, a weak positive correlation with disease activity was seen in barley (r = 0.261; p = 0.042).Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Crohn's disease clinical activity. 
背景:炎症性肠病(IBD)是一种受食物影响的自身免疫性疾病,肠道炎症通过抗原-抗体复合物的形成加速其临床疾病活动性的重要因素。食物特异性IgG检测可以确定可能导致疾病活动的人的食物消费类型。它对治疗IBD是有用的,而不会有营养不良的风险,因为它是根据个人免疫状况量身定制的。方法:这是一项横断面研究,涉及113例通过结肠镜检查诊断为IBD的患者。采用ELISA和免疫阵列技术对220种食品进行血清IgG特异性检测。采用Mayo指数和克罗恩病活动性指数评估疾病临床活动性。结果:克罗恩病中IgG的比例最高的是豌豆(100%)、大麦(97.9%)、鸡蛋(95.9%)、牛奶(81.6%)和玉米(75.5%);而在溃疡性结肠炎中,大麦(98.4%),豌豆(96.8%),蛋白(92.2%),玉米(82.8%)和梅干(78.1%)。在溃疡性结肠炎中,腰果IgG与溃疡性结肠炎呈弱负相关(r = -0.347;p = 0.041)和鹰嘴豆IgG (r = -0.473;P = 0.017);而在克罗恩病中,大麦与疾病活动呈弱正相关(r = 0.261;P = 0.042)。结论:腰果和鹰嘴豆特异性IgG抗体与溃疡性结肠炎临床活动性呈弱负相关,大麦特异性IgG抗体与克罗恩病临床活动性呈弱正相关。
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引用次数: 0
Effects of Continuous Positive Airway Pressure on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Systematic Review 持续气道正压对阻塞性睡眠呼吸暂停患者非酒精性脂肪性肝病的影响:一项系统综述
S. Tamin, Sabda Ardiantara, Diar Riyanti Rudiatmoko
Background: Nonalcoholic fatty liver disease (NAFLD) is associated with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the first-line therapy for OSA. However, the effect of CPAP on NAFLD in patients with concomitant OSA is still unclear. This study aims to identify the use of CPAP on NAFLD in patients with OSA. Method: A systematic literature search was performed using particular keywords and medical subheadings in three journal databases: Cochrane, PubMed, and EBSCOhost. The results were screened and assessed using inclusion and exclusion criteria by three independent authors. The Randomized controlled trial (RCT) quality was evaluated with Jadad scale and the cohort studies quality was assessed with Newcastle-Ottawa quality assessment scale.Results:  Two RCTs and three cohort studies were eligible to fulfil the inclusion criteria, consisting of 620 total patients. Two RCTs showed no statistically significant improvement after CPAP treatment in NAFLD based on intrahepatic triglyceride (measured by proton magnetic resonance spectroscopy), liver stiffness measurement, serum cytokeratin-18 fragment, and liver function blood test parameters. Meanwhile, 2 cohort studies in adults and 1 cohort study in children showed significant improvement in ALT, AST, and APRI. However, one cohort study showed no significant improvement in serum fibrosis markers and transient elastography measurement after CPAP treatment.Conclusion: CPAP might be beneficial in some patients with OSA to improve NAFLD, but further research that includes many subjects and longer duration of CPAP therapy is needed to confirm this result.
背景:非酒精性脂肪性肝病(NAFLD)与阻塞性睡眠呼吸暂停(OSA)相关。持续气道正压通气(CPAP)是OSA的一线治疗方法。然而,CPAP对合并OSA患者NAFLD的影响尚不清楚。本研究旨在确定CPAP在阻塞性睡眠呼吸暂停(OSA) NAFLD患者中的应用。方法:在Cochrane、PubMed和EBSCOhost三个期刊数据库中使用特定的关键词和医学副标题进行系统的文献检索。结果由三位独立作者使用纳入和排除标准进行筛选和评估。随机对照试验(RCT)质量评价采用Jadad量表,队列研究质量评价采用Newcastle-Ottawa质量评价量表。结果:2项随机对照试验和3项队列研究符合纳入标准,共纳入620例患者。两项随机对照试验显示,基于肝内甘油三酯(质子磁共振波谱测量)、肝脏硬度测量、血清细胞角蛋白-18片段和肝功能血液检查参数,CPAP治疗后NAFLD无统计学意义的改善。同时,2项成人队列研究和1项儿童队列研究显示ALT、AST和APRI均有显著改善。然而,一项队列研究显示,CPAP治疗后血清纤维化标志物和瞬时弹性成像测量没有显著改善。结论:CPAP可能对部分OSA患者有改善NAFLD的作用,但需要更多受试者和更长时间CPAP治疗的进一步研究来证实这一结果。
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引用次数: 0
Multimodal Treatment of Cystic Echinococcosis 囊性包虫病的多模式治疗
Anak Agung Ketut Yunita Paramita, I. Wibawa
Cystic echinococcosis is a zoonotic disease that is caused by the larval stages of cestodes species and belongs to the genus Echinococcus. Echinococcus granulosus (E. granulosus) causes cystic echinococcosis which is global and wider in its distribution than alveolar echinococcosis. Endemic areas of E. granulosus are Russia, Eastern Europe, the Middle East, China, and South America based on data from the World Health Organization (WHO). Incidence rates are 50 per 100,000 person-years. The life cycle of E. granulosus requires both an intermediate host and a definitive host. A human accidentally becomes an intermediate host. Upon infection, cyst formation mostly occurs in the liver (70%). At the first, the infection is usually asymptomatic. Diagnosis of cystic echinococcosis can be done by imaging techniques (ultrasound or CT/MRI), serum serologic testing for antibodies against hydatid antigens, and immunologic testing. In general, there are four different management modalities for cystic echinococcosis, such as surgery, percutaneous therapy surgery, chemotherapy, and watchful waiting.
囊性棘球绦虫病是一种由棘球绦虫幼虫引起的人畜共患疾病,属于棘球绦虫属。细粒棘球绦虫(E. granulosus)引起囊性棘球蚴病,它是全球性的,分布比肺泡性棘球蚴病更广泛。根据世界卫生组织(WHO)的数据,颗粒棘球绦虫的流行地区是俄罗斯、东欧、中东、中国和南美。发病率为每10万人年50人。细粒棘球绦虫的生命周期既需要中间寄主,也需要最终寄主。一个人意外地成为了中间宿主。感染后,囊肿主要发生在肝脏(70%)。起初,感染通常是无症状的。囊性包虫病的诊断可以通过成像技术(超声或CT/MRI)、针对包虫病抗原的血清血清学检测和免疫检测来完成。一般来说,囊性包虫病有四种不同的治疗方式,如手术、经皮治疗、手术、化疗和观察等待。
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引用次数: 1
Effectivity of Extracorporeal Shock Wave Lithotripsy and Stenting vs Stenting Only for Difficult Common Biliary Duct Stones: A Retrospective Analysis 体外冲击波碎石联合支架置入与单纯支架置入治疗难治性胆总管结石的疗效:回顾性分析
H. Maulahela, D. Rumagesan, M. Abdullah, D. Makmun, Kaka Renaldi, M. Simadibrata, H. Shatri, A. Fauzi
Background: This study is conducted to investigate the effectiveness of extracorporeal shockwave lithotripsy (ESWL) after biliary stent placement compared to biliary stent placement alone in difficult common bile duct stones.Method: This is a retrospective cohort study using medical record data from the Gastrointestinal Endoscopy Center Registry of Dr. Cipto Mangunkusumo General National Hospital. We retrospectively evaluated 126 subjects with difficult bile stones. The subjects were divided into two groups: subjects subjected to biliary stent placement only and subjects who underwent ESWL procedure after the biliary stent placement. The effectiveness of the procedures was measured in the form of total clearance of bile stones.Results: A total of 126 subjects were included in this study, including 72 subjects who underwent ESWL procedure after biliary stent placement and 54 subjects who underwent biliary stent placement only. The effectiveness of ESWL after biliary stent placement in achieving total clearance was 69.1%, and the effectiveness of biliary stent placement in achieving total clearance was 64.8%. The ESWL procedure as adjuvant therapy after biliary stent placement did not provide a statistically significant difference (p = 0.703; 95% CI: 0.816–1.351). Normal body mass index was a factor that influences the effectiveness of ESWL after biliary stent placement (p = 0.002).Conclusion: The ESWL procedure as adjuvant therapy after biliary stent placement has the same level of effectiveness as biliary stent placement alone.
背景:本研究旨在探讨胆总管支架置入术后体外冲击波碎石术(ESWL)与单独置入术治疗难治性胆总管结石的疗效。方法:这是一项回顾性队列研究,使用了Cipto Mangunkusumo博士国立综合医院胃肠道内窥镜中心登记处的病历数据。我们回顾性评估了126例难治性胆结石患者。受试者被分为两组:仅行胆道支架置入术的受试者和胆道支架置入术后行ESWL的受试者。手术的有效性以胆结石总清除率的形式来衡量。结果:本研究共纳入126名受试者,其中72名受试者在胆道支架置入后行ESWL手术,54名受试者仅行胆道支架置入。胆道支架置入后ESWL达到总清除率的有效率为69.1%,胆道支架置入后ESWL达到总清除率的有效率为64.8%。ESWL手术作为胆道支架置入术后的辅助治疗没有统计学意义(p = 0.703;95% ci: 0.816-1.351)。正常体重指数是影响胆道支架置入术后ESWL效果的因素(p = 0.002)。结论:ESWL作为胆道支架置入术后的辅助治疗与单独置入术的效果相同。
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引用次数: 0
Correlation of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) with Liver Transient Elastography Results in Evaluating Liver Fibrosis in Chronic Hepatitis B Patients Mac-2结合蛋白糖基化异构体(M2BPGi)与肝脏瞬时弹性成像结果评估慢性乙型肝炎患者肝纤维化的相关性
Haryono Haryono, M. B. Bestari, N. Agustanti, Dolvy Girawan, Yudi Wahyudi, S. Abdurachman, Anna Tjandrawati
Background: Hepatitis B virus (HBV) is a serious health problem in the world, including in Indonesia. Transient elastography (TE) is now regarded as a reliable surrogate marker for grading the severity of liver fibrosis in chronic hepatitis B (CHB) patients. The Mac-2 binding protein of glycosylation isomer (M2BPGi) is a novel non-invasive serum biomarker for liver fibrosis staging in various liver diseases including CHB. This study aims to evaluate the correlation of M2BPGi and liver stiffness (LS), measured through TE, in predicting liver fibrosis among CHB patients.Method: A cross-sectional study was conducted at Dr. Hasan Sadikinl General Hospital Bandung between September 2021–January 2022 on patients diagnosed with CHB based on clinical and biochemical examination. The subjects underwent TE examination using Fibroscan® and M2BPGi levels were determined with an automated immunoassay analyzer HISCL-800, Sysmex, Japan. Statistical analysis was conducted using the Spearman rank correlation method with a significance value of p 0.05.Results: A total of 119 CHB (M:F = 66:53, median age 43 years) patients were consecutively recruited. The median M2BPGi level was 1.04 COI (0.74–1.59) and the median of LS was 7.3 (5.6–12.5). M2BPGi had a moderate and significant correlation with LS (r = 0.525; p 0.001). Median M2BPGi values in each fibrosis stage were 0.89 COI in F0-F1, 0.88 in F2, 1.61 in F3, and 2.24 in F4 (p 0.001).Conclusion: This study revealed a moderate positive correlation between serum M2BPGi level and LS in CHB patients.
背景:乙型肝炎病毒(HBV)在世界范围内是一个严重的健康问题,包括在印度尼西亚。瞬时弹性成像(TE)现在被认为是慢性乙型肝炎(CHB)患者肝纤维化严重程度分级的可靠替代标志物。糖基化异构体Mac-2结合蛋白(M2BPGi)是一种新的无创血清生物标志物,可用于包括慢性乙型肝炎在内的各种肝脏疾病的肝纤维化分期。本研究旨在评估M2BPGi与肝脏硬度(LS)(通过TE测量)在预测CHB患者肝纤维化中的相关性。方法:于2021年9月至2022年1月在万隆市Hasan Sadikinl总医院对经临床和生化检查诊断为慢性乙型肝炎的患者进行横断面研究。受试者使用Fibroscan®进行TE检查,M2BPGi水平由日本Sysmex公司的自动免疫分析仪HISCL-800检测。统计学分析采用Spearman秩相关法,p值为0.05。结果:共纳入119例CHB患者(M:F = 66:53,中位年龄43岁)。M2BPGi中位值为1.04 COI (0.74-1.59), LS中位值为7.3(5.6-12.5)。M2BPGi与LS呈中度显著相关(r = 0.525;p 0.001)。各纤维化期M2BPGi值中位数F0-F1为0.89 COI, F2为0.88,F3为1.61,F4为2.24 (p < 0.001)。结论:本研究显示CHB患者血清M2BPGi水平与LS呈正相关。
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引用次数: 0
Diagnosis and Management of Chylous Ascites 乳糜腹水的诊断和治疗
Chylous ascites (CA) is a rare form of ascites that results from the leakage of lipid-rich lymph into the peritoneal cavity. This usually occurs due to trauma and rupture of the lymphatics or increased peritoneal lymphatic pressure secondary to obstruction. The underlying etiologies for CA have been classified as traumatic, congenital, infectious, neoplastic, postoperative, cirrhotic or cardiogenic. Since malignancy and cirrhosis account for about two-thirds of all the cases of CA in Western countries. The diagnosis of CA is based on the distinct characteristic of the ascitic fluid which includes a milky appearance and a triglyceride level of 200 mg/dL. The management consists of identifying and treating the underlying disease process, dietary modification, and diuretics. Treatment with nutritional optimization and management of the underlying etiology are the cornerstones of therapy. When conservative measures fail, other interventions such as octreotide/somatostatin analogues, surgical ligation, embolization and transjugular intrahepatic portosystemic shunt in patients with cirrhosis can be considered.
乳糜腹水(CA)是一种罕见的腹水形式,由富含脂质的淋巴渗漏到腹膜腔引起。这通常是由于创伤和淋巴破裂或继发于梗阻的腹膜淋巴压力增加而发生的。CA的潜在病因分为外伤性、先天性、感染性、肿瘤性、术后、肝硬化或心源性。在西方国家,恶性肿瘤和肝硬化约占所有CA病例的三分之二。CA的诊断是基于腹水的明显特征,包括乳白色外观和甘油三酯水平200mg /dL。管理包括识别和治疗潜在的疾病过程,饮食调整和利尿剂。营养优化治疗和潜在病因的管理是治疗的基石。当保守措施失败时,可以考虑其他干预措施,如奥曲肽/生长抑素类似物、手术结扎、栓塞和经颈静脉肝内门静脉分流术。
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引用次数: 0
The Prevalence and Risk Factors of Gastric Polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital 坎都医院内窥镜科胃息肉患病率及危险因素分析
Background: Gastric polyps are usually asymptomatic; they are often incidentally discovered during an esophagogastroduodenoscopy (EGD) for other indication. Most of gastric polyps are benign, however, some have malignant potential. Therefore, identifying gastric polyp risk factors are crucial. This article aims to determine the prevalence and risk factor of gastric polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital between April 2021-2022.Method: The retrospective study was using medical record data of all patients who underwent EGD between April 2021-2022. Data regarding patient’s characteristic, endoscopic finding, and risk factors were collected. Data was analyzed using SPSSv25.0 with Mann-Whitney, Chi-square-test, and logistic-regression.Results: There were 241 patients included, 56.4% were males. The median age was 53 years old. The most common symptom was epigastric pain (69.3%). The main indication of EGD was dyspepsia with alarm symptoms (79.25%). We found 24.1% of patients had gastric polyps. Most polyps were found in corpus (93.1%) and 70.7% were fundic gland polyp. We found that older age (p=0.001), female (p=0.003), gastritis (p=0.037), active-smoker (p=0.000), and one-year-PPI-usage (p=0.000) were significantly associated with gastric polyp. Logistic-regression analysis showed active smoking was the most significant risk factor (OR=9.3), followed by female gender (OR=6.4), and PPI-usage (OR=3.4). We found no significant association between esophagitis, bile-reflux, gastric ulcer, H. pylori infection, NSAID use, and alcohol abuse with gastric polyp.Conclusions: We found 24.1% gastric polyp prevalence with significant risk factors such as older age, female gender, gastritis, smoking, and long-term-PPI-usage.
背景:胃息肉通常无症状;它们通常是在食管胃十二指肠镜检查(EGD)中偶然发现的。大多数胃息肉是良性的,但也有一些可能是恶性的。因此,确定胃息肉的危险因素至关重要。本文旨在确定2021年4月至2022年4月期间Dr. R.D. Kandou医院内窥镜科胃息肉的患病率及危险因素。方法:回顾性研究使用2021-2022年4月期间所有EGD患者的病历资料。收集了患者的特征、内窥镜检查结果和危险因素的数据。采用SPSSv25.0进行数据分析,采用Mann-Whitney检验、卡方检验和logistic回归。结果:共纳入241例患者,男性占56.4%。平均年龄为53岁。最常见的症状是胃脘痛(69.3%)。EGD的主要指征为消化不良伴惊恐症状(79.25%)。我们发现24.1%的患者有胃息肉。息肉多见于体部(93.1%),其中70.7%为基底腺息肉。我们发现,年龄较大(p=0.001)、女性(p=0.003)、胃炎(p=0.037)、活跃吸烟者(p=0.000)和一年ppi使用(p=0.000)与胃息肉显著相关。logistic回归分析显示,吸烟是最显著的危险因素(OR=9.3),其次是女性(OR=6.4)和使用ppi (OR=3.4)。我们发现食管炎、胆汁反流、胃溃疡、幽门螺杆菌感染、使用非甾体抗炎药和酗酒与胃息肉之间没有显著的关联。结论:我们发现24.1%的胃息肉患病率具有显著的危险因素,如年龄较大、女性、胃炎、吸烟和长期使用ppi。
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引用次数: 0
Recurrent Esophageal Stricture as a Result of Esophageal Diverticulum: Case Report 食道憩室所致食道狭窄复发1例
Esophageal stricture is a disorder that limiting patients’ capability to get adequate intake. Dysphagia and regurgitation are main problem that makes patient admit to the hospital. There are several causes that narrowing esophageal lumen; those could be intraluminal or extraluminal. Esophageal diverticulum is one of a kind. It is not easy to establish the diagnosis of diverticulum in esophagus segment since supporting examination needed were complex. Esophageal stricture treatment should be interdisciplinary approach because inappropriate management would increase risk of complication and lowering patient’s quality of life. The management of esophageal diverticulum could be challenging and its prognosis depends on the patient’s characteristic and comorbidity.
食道狭窄是一种限制患者摄取足够食物的疾病。吞咽困难和反流是使患者住院的主要问题。引起食管腔狭窄的原因有很多;可以是腔内或腔外。食管憩室是其中的一种。食管段憩室的诊断不容易,需要的辅助检查复杂。食管狭窄的治疗应多学科结合,因为处理不当会增加并发症的风险,降低患者的生活质量。食管憩室的治疗可能具有挑战性,其预后取决于患者的特点和合并症。
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引用次数: 0
期刊
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
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