Effects of a vascular disrupting agent for cancer treatment on normal tissue evaluated by PIXE analysis using quantum dots

International Journal of PIXE Pub Date : 2014-01-01 DOI:10.1142/S0129083514500077

A. Terakawa, K. Ishii, S. Matsuyama, Y. Kikuchi, K. Kusano, M. Karahashi, Y. Nozawa, S. Yamauchi, K. Kikuchi, S. Furumoto, Y. Funaki, N. Ito, S. Wada, K. Sera

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引用次数: 2

Abstract

The effects of the vascular disrupting agent AVE8062 on tumor and normal tissue samples were investigated by particle-induced X-ray emission (PIXE) analysis using quantum dots (QDs). We investigated fibrosarcoma tumors in mice, and used kidney tissue as a control. Non-targeted QDs were used to characterize the tissue regions where blood flow is interrupted by AVE8062. We found that the concentration of the QDs in the tumors and kidneys exposed to AVE8062 was lower than that of the control group. Sub-millimeter PIXE analysis (with a beam size of 0.5 × 0.5 mm2) was used to investigate the spatial distribution of QDs in the tissue samples. We found that the QDs were accumulated in localized regions of the kidney section of the AVE8062-treated group whereas the QDs were uniformly distributed in the control kidney. This suggests that AVE8062 caused blood flow interruption not only in the tumor samples but also in the normal blood vessels in the kidneys.

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利用量子点的PIXE分析评估用于癌症治疗的血管破坏剂对正常组织的影响

采用量子点(QDs)粒子诱导x射线发射(PIXE)技术研究了血管干扰剂AVE8062对肿瘤和正常组织样品的影响。我们研究了小鼠纤维肉瘤肿瘤，并使用肾脏组织作为对照。非靶向量子点用于表征AVE8062阻断血流的组织区域。我们发现AVE8062暴露的肿瘤和肾脏中QDs的浓度低于对照组。亚毫米pixie分析(光束尺寸为0.5 × 0.5 mm2)用于研究组织样品中量子点的空间分布。我们发现，ave8062处理组的量子点集中在肾脏局部区域，而对照组的量子点则均匀分布。这表明AVE8062不仅在肿瘤样本中引起血流中断，而且在肾脏的正常血管中也引起血流中断。

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International Journal of PIXE

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