Diogo Cruz , Francisca Monteiro , Maria Paço , Manuel Vaz-Silva , Carolina Lemos , Miguel Alves-Ferreira , Teresa Pinho
{"title":"Genetic overlap between temporomandibular disorders and primary headaches: A systematic review","authors":"Diogo Cruz , Francisca Monteiro , Maria Paço , Manuel Vaz-Silva , Carolina Lemos , Miguel Alves-Ferreira , Teresa Pinho","doi":"10.1016/j.jdsr.2022.02.002","DOIUrl":null,"url":null,"abstract":"<div><p>Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were <em>COMT, MTHFR,</em> and <em>ESR1. COMT</em> was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of <em>MTHFR</em> gene regulation on either TMD or PHD was found. The most robust results are concerning the <em>ESR1</em> gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of <em>ESR1</em> and <em>COMT</em> genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 69-88"},"PeriodicalIF":5.7000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000035/pdfft?md5=49dcb79f9dbacdad92d3650afb67ca21&pid=1-s2.0-S1882761622000035-main.pdf","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Dental Science Review","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1882761622000035","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 7
Abstract
Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were COMT, MTHFR, and ESR1. COMT was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of MTHFR gene regulation on either TMD or PHD was found. The most robust results are concerning the ESR1 gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of ESR1 and COMT genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.
期刊介绍：
The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
