FORMULATION DEVELOPMENT AND OPTIMIZATION OF VALSARTAN TABLETS EMPLOYING βCD STARCH 1500 AND SOLUPLUS

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2017-09-01 DOI:10.20959/WJPPS20179-10116

Chowdary K. P. R.

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引用次数: 1

Abstract

The objective of the present study is optimization of Valsartan tablet formulation employing βCD, Starch 1500, and Soluplus by 2 3 factorial design to achieve NLT 85% dissolution in 10 min. Eight Valsartan tablet formulations were prepared using selected combinations of the three factors as per 2 3 factorial design. Valsartan tablets were prepared by direct compression method and were evaluated. The individual and combined effects of the three factors βCD, Starch 1500 and Soluplus are highly significant (P < 0.01) in influencing the dissolution rate of Valsartan tablets. Valsartan tablet formulations Fb,Fab, Fbc and Fabc disintegrated rapidly and gave very rapid dissolution of Valsartan, 92.4%, 99.4%, 96.2% and 99.2% in 10 min respectively. The increasing order of dissolution rate (K1) observed with various formulations was F1< Fc< Fa< Fac< Fb< Fbc< Fab

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采用β - cd淀粉1500和溶液加成剂制备缬沙坦片剂

以βCD、Starch 1500、Soluplus为主要成分，采用23因子设计优化缬沙坦片剂配方，使其在10 min内溶出度达到85%。根据23因子设计，选择3个因素的组合，制备8个缬沙坦片剂配方。采用直接压缩法制备缬沙坦片，并对其进行评价。βCD、Starch 1500、Soluplus三个因子对缬沙坦片溶出度的影响分别为极显著(P < 0.01)和极显著(P < 0.01)。缬沙坦片配方Fb、Fab、Fbc和Fabc崩解速度快，10 min内缬沙坦溶出度分别为92.4%、99.4%、96.2%和99.2%。不同配方的溶出速率K1的增大顺序为F1< Fc< Fa< Fac< Fb< Fbc< Fab

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World journal of Pharmacy and pharmaceutical sciences

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