Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review

Anshul Sharma, Keshav Dhiman, Kamya Goyal, V. Pandit, M. Ashawat, Shammy Jindal
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Abstract

Liposomes are the nano-scale bilayer structure of phospholipid used as a carrier for a Large Variety of drugs. Both lipophilic and hydrophilic drugs can encapsulate into the liposome and delivered to the body. The purpose behind the preparation of liposomes is to reduce the side effects associated with systemic delivery of drugs as well as it also helps in the protection of biodegradable drugs and molecules such as protein and peptides from body enzymes and fluids. Other than these advantages liposome also have high skin permeation due to structural similarities with the stratum corneum and therefore can be used for the topical delivery of drugs. The various types of liposomes and their application in their marketed products are discussed below in the article.
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纳米载体在药物开发中的应用(以脂质体为重点
脂质体是一种纳米级双层结构的磷脂,用作多种药物的载体。亲脂性和亲水性药物均可包封在脂质体内并输送到体内。制备脂质体的目的是为了减少与药物全身递送相关的副作用,同时也有助于保护可生物降解的药物和分子,如蛋白质和肽,免受体内酶和液体的影响。除了这些优点外,脂质体由于与角质层结构相似,还具有较高的皮肤渗透性,因此可用于局部给药。本文讨论了各种类型的脂质体及其在上市产品中的应用。
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