Detection of P-Cresol in Solution for Peritoneal Dialysis

Abstract

p-Cresol is a metabolite which is synthesized by be intestinal bacteria in the small intestine from 4-hydroxyphenylacetate acid. During metabolism this substrate is filtered by kidneys and leaves the organism with urine. In case of chronic kidney decease p-cresol accumulates in body fluids and has to be removed by means of dialysis. To estimate p-cresol clearance and the efficiency of dialysis methods concentration of this substrate has to be measured and controlled. The possibility of p-cresol detection and elimination by means of cyclic voltammetry method was investigated. It is shown that graphite electrodes can be used for p-cresol’s detection and evaluation. p-Cresol oxidation peak was observed near potential 650 mV against saturated Ag/AgCl-electrode. Influence of p-cresol concentration on oxidation peak height was also investigated. Suggested technique can be used for dialysate regeneration efficiency control.