Outcome of High Dose Ampicillin-Sulbactam and Colistin Combination Therapy for Treating Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii: a Pilot Study

Q3 Medicine Pediatric Infection and Vaccine Pub Date : 2020-05-02 DOI:10.14776/piv.2020.27.e5

S. Jeong, Young A Kim, Go-eun Choi, Su Eun Park

{"title":"Outcome of High Dose Ampicillin-Sulbactam and Colistin Combination Therapy for Treating Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii: a Pilot Study","authors":"S. Jeong, Young A Kim, Go-eun Choi, Su Eun Park","doi":"10.14776/piv.2020.27.e5","DOIUrl":null,"url":null,"abstract":"Purpose: This pilot study aimed to evaluate the efficacy of high-dose ampicillin/-sulbactam and colistin combination therapy for treating ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) in the pediatric intensive care unit of Pusan National University Children's Hospital. Methods: We retrospectively reviewed 17 pediatric patients VAP with caused by CRAB from June 2017 to August 2018. 10 (58.8%) patients were treated with high dose ampicillinsulbactam and colistin combination (combination therapy group), and 7 were treated with colistin only, or various combination of with or without colistin (other antibiotics group). Clinical and bacteriological outcome were compared between groups. Results: The mean duration of fever after antibiotic use was 1.30±1.70 days in the combination therapy group and 1.71±1.49 days in the other antibiotics group. The mean duration of days for negative conversion of endotracheal aspirate bacterial culture after Pediatr Infect Vaccine. 2020 Apr;27(1):e5 https://doi.org/10.14776/piv.2020.27.e5 pISSN 2384-1079·eISSN 2384-1087","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Infection and Vaccine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14776/piv.2020.27.e5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 1

Abstract

Purpose: This pilot study aimed to evaluate the efficacy of high-dose ampicillin/-sulbactam and colistin combination therapy for treating ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) in the pediatric intensive care unit of Pusan National University Children's Hospital. Methods: We retrospectively reviewed 17 pediatric patients VAP with caused by CRAB from June 2017 to August 2018. 10 (58.8%) patients were treated with high dose ampicillinsulbactam and colistin combination (combination therapy group), and 7 were treated with colistin only, or various combination of with or without colistin (other antibiotics group). Clinical and bacteriological outcome were compared between groups. Results: The mean duration of fever after antibiotic use was 1.30±1.70 days in the combination therapy group and 1.71±1.49 days in the other antibiotics group. The mean duration of days for negative conversion of endotracheal aspirate bacterial culture after Pediatr Infect Vaccine. 2020 Apr;27(1):e5 https://doi.org/10.14776/piv.2020.27.e5 pISSN 2384-1079·eISSN 2384-1087

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

大剂量氨苄青霉素-舒巴坦联合粘菌素治疗耐碳青霉烯鲍曼不动杆菌引起的呼吸机相关性肺炎的疗效:一项初步研究

目的:本研究旨在评价大剂量氨苄西林/舒巴坦联合粘菌素治疗釜山大学儿童医院儿科重症监护病房耐碳青霉烯鲍曼不动杆菌(CRAB)所致呼吸机相关性肺炎(VAP)的疗效。方法:回顾性分析2017年6月至2018年8月17例小儿由螃蟹引起的VAP。采用大剂量氨苄菌巴坦联合粘菌素治疗的患者10例(58.8%)(联合治疗组)，单纯使用粘菌素或多种联用或不使用粘菌素治疗的患者7例(其他抗生素组)。比较两组临床及细菌学结果。结果:联合用药组发热持续时间平均为1.30±1.70 d，单独用药组发热持续时间平均为1.71±1.49 d。张建军。小儿感染疫苗接种后气管内吸出细菌培养阴性转化平均天数[j] .2020年4月;27(1):e5 https://doi.org/10.14776/piv.2020.27.e5 pISSN 2384-1079·eISSN 2384-1087

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.