Pediatric Infection and Vaccine最新文献

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A Rare Case of Brain Abscess Caused by Aggregatibacter aphrophilus and Actinomyces georgiae in an Immunocompetent Child 免疫功能正常儿童嗜aphrophilus聚集菌及放线菌所致脑脓肿一例

Q3 Medicine

Pediatric Infection and Vaccine

Pub Date : 2023-01-01 DOI: 10.14776/piv.2023.30.e16

Soojeong Bae, Su Jin Lee, Ye Kyung Kim, Hee-Won Moon, Kyung Rae Cho, Ran Lee

引用次数: 0

Severe Human Rhinovirus Lower Respiratory Tract Infections in Young Children 幼儿严重人鼻病毒下呼吸道感染

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Pediatric Infection and Vaccine

Pub Date : 2023-01-01 DOI: 10.14776/piv.2023.30.e17

Doo Ri Kim, Kyung-Ran Kim, Hwanhee Park, Esther Park, Joongbum Cho, Jihyun Kim, Hee Jae Huh, Kangmo Ahn, Nam Yong Lee, Yae-Jean Kim

引用次数: 0

Acute Appendicitis: A Rare But Probable Manifestation of Kawasaki Disease 急性阑尾炎:川崎病罕见但可能的表现

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Pediatric Infection and Vaccine

Pub Date : 2023-01-01 DOI: 10.14776/piv.2023.30.e9

Wonshik Choi, Sin Weon Yun, Mineui Hong, Suk-Won Suh, Dae Yong Yi, Ji Young Park

引用次数: 0

CD45RA+ Depleted Lymphocyte Infusion for Treatment of Refractory Cytomegalovirus Disease in Complete DiGeorge Syndrome: A Case Report CD45RA+贫淋巴细胞输注治疗难治性巨细胞病毒病完全性迪乔治综合征1例

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Pediatric Infection and Vaccine

Pub Date : 2023-01-01 DOI: 10.14776/piv.2023.30.e18

HyungJin Chin, Young Hye Ryu, Da Yun Kang, Hyun Jin Park, Kyung Taek Hong, Jung Yoon Choi, Ki Wook Yun, Bongjin Lee, Hyoung Jin Kang, Eun Hwa Choi

引用次数: 0

Acute Hemorrhagic Edema of Infancy Associated With Coronavirus Disease 2019 与2019冠状病毒病相关的婴儿急性出血性水肿

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Pediatric Infection and Vaccine

Pub Date : 2023-01-01 DOI: 10.14776/piv.2023.30.e14

Jong Ki Jung, Young June Choe, Hwa Jung Ryu, Won-Hee Seo

引用次数: 0

Clinical and Epidemiological Characteristics of Common Human Coronaviruses in Children: A Single Center Study, 2015–2019 儿童常见人类冠状病毒的临床和流行病学特征：一项单中心研究，2015-2019

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Pediatric Infection and Vaccine

Pub Date : 2021-08-01 DOI: 10.14776/piv.2021.28.e10

Y. Choi, Y. Kim, E. Choi

Purpose: Common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given the lack of local epidemiology data on common HCoVs, we aimed to describe clinical and epidemiological characteristics of common HCoVs in children. Methods: Respiratory viral test results from 9,589 respiratory samples from Seoul National University Children's Hospital were analyzed from January 2015 to December 2019. Viral detection was done by the multiplex reverse transcription polymerase chain reaction. Demographics and clinical diagnosis were collected for previously healthy children tested positive for HCoVs. Results: Of the 9,589 samples tested, 1 or more respiratory viruses were detected from 5,017 (52.3%) samples and 463 (4.8%) samples were positive for HCoVs (OC43 2.8%, NL63 1.4%, 229E 0.7%). All 3 types co-circulated during winter months (November to February) with some variation by type. HCoV-OC43 was the most prevalent every winter season. HCoV-NL63 showed alternate peaks in late winter (January to March) and early winter (November to February). HCoV-229E had smaller peaks every other winter. Forty-one percent of HCoV-positive samples were co-detected with additional viruses;human rhinovirus 13.2%, respiratory syncytial virus 13.0%, influenza virus 4.3%. Common clinical diagnosis was upper respiratory tract infection (60.0%) followed by pneumonia (14.8%), croup (8.1%), and bronchiolitis (6.7%). Croup accounted for 17.0% of HCoV-NL63-positive children. Conclusions: This study described clinical and epidemiological characteristics of common HCoVs (OC43, NL63, 229E) in children. Continuing surveillance, perhaps by adding HKU1 in the diagnostic panel can further elucidate the spectrum of common HCoV infections in children. © 2021 The Korean Society of Pediatric Infectious Diseases.

目的：常见的人类冠状病毒（HCoV）由于其感染性质温和，研究相对不足。鉴于缺乏常见HCoV的当地流行病学数据，我们旨在描述儿童常见HCo病毒的临床和流行病学特征。方法：分析2015年1月至2019年12月首尔国立大学儿童医院9589份呼吸道样本的呼吸道病毒检测结果。病毒检测采用多重逆转录聚合酶链式反应。收集了HCoV检测呈阳性的先前健康儿童的人口学和临床诊断。结果：在9589份检测样本中，5017份（52.3%）样本中检测到1种或1种以上呼吸道病毒，463份（4.8%）样本中HCoV呈阳性（OC43 2.8%，NL63 1.4%，229E 0.7%）。所有3种类型在冬季月份（11月至2月）共同传播，并因类型而异。HCoV-OC43在每个冬季最为流行。HCoV-NL63在冬末（1月至3月）和初冬（11月至2月）出现交替高峰。HCoV-229E每隔一个冬天出现一次较小的峰值。41%的HCoV阳性样本与其他病毒共同检测到；人类鼻病毒13.2%，呼吸道合胞病毒13.0%，流感病毒4.3%。常见的临床诊断是上呼吸道感染（60.0%），其次是肺炎（14.8%）、臀部（8.1%）和细支气管炎（6.7%）。croup占HCoV-NL63阳性儿童的17.0%。结论：本研究描述了儿童常见HCoV（OC43，NL63229E）的临床和流行病学特征。继续监测，也许通过在诊断小组中添加HKU1，可以进一步阐明儿童常见HCoV感染的谱。©2021韩国儿科传染病学会。

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引用次数: 2

BioFire® Meningitis/Encephalitis Panel의 진단적 유용성 평가: 90일 미만 발열 영아에서의 예비 연구 BioFire®Meningitis/Encephalitis Panel的诊断有用性评价:对发热90天婴儿的初步研究

Q3 Medicine

Pediatric Infection and Vaccine

Pub Date : 2021-08-01 DOI: 10.14776/PIV.2021.28.E9

김 경민, 박 지영, 박 경운, 손 영주, 최 윤영, 한 미선, 최 은화

引用次数: 1

Multisystem Inflammatory Syndrome in Children (MIS-C) 儿童多系统炎症综合征（MIS-C）

Q3 Medicine

Pediatric Infection and Vaccine

Pub Date : 2021-08-01 DOI: 10.14776/piv.2021.28.e13

J. Lee, E. Cho, Hyunju Lee

The coronavirus disease 2019 pandemic has been continuously spreading throughout the world. As of July 15, 2021, there have been more than 188 million confirmed cases and more than 4.06 million deaths. Although the incidence of severe infections is relatively low in children and adolescents compared to adults, a complication called multisystem inflammatory syndrome in children (MIS-C) may occur in some cases at approximately 2–6 weeks after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. MIS-C can be seen in patients of various ages, from young infants to adolescents, and may present with diverse clinical manifestations. While fever present in a great majority of patients, symptoms suggesting the involvement of the digestive or nervous system and the skin and mucous membranes (Kawasaki disease-like symptoms) also appear in many cases. Cardiac involvement may also be observed, including left ventricular dysfunction, myocarditis, coronary artery dilatation, and coronary aneurysm. In some cases, hypotension or shock can occur, and mechanical ventilation or treatment in the intensive care unit may be necessary. Fortunately, recovery is generally reported after appropriate treatment. MIS-C is a rare but important complication of SARS-CoV-2 infection in children and adolescents. As such, it is important to recognize the clinical symptoms and provide appropriate treatment at an early stage. In this review, the epidemiology, clinical symptoms, suggested pathophysiology, diagnostic approach, and treatment of MIS-C will be discussed. © 2021 The Korean Society of Pediatric Infectious Diseases.

2019冠状病毒病大流行在全球持续蔓延。截至2021年7月15日，确诊病例超过1.88亿例，死亡病例超过406万例。尽管与成人相比，儿童和青少年的严重感染发生率相对较低，但在一些病例中，在感染严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)后约2-6周，可能会出现一种称为儿童多系统炎症综合征(MIS-C)的并发症。MIS-C可以在不同年龄的患者中看到，从幼儿到青少年，可能表现出不同的临床表现。虽然绝大多数患者出现发烧，但许多病例也出现消化系统或神经系统以及皮肤和粘膜受累的症状(类似川崎病的症状)。心脏受累也可观察到，包括左心室功能障碍、心肌炎、冠状动脉扩张和冠状动脉瘤。在某些情况下，可能发生低血压或休克，可能需要在重症监护病房进行机械通气或治疗。幸运的是，经过适当的治疗后，一般都能恢复。MIS-C是儿童和青少年感染SARS-CoV-2的罕见但重要的并发症。因此，认识到临床症状并在早期阶段提供适当的治疗是很重要的。本文将对MIS-C的流行病学、临床症状、建议的病理生理、诊断方法和治疗进行讨论。©2021韩国儿科传染病学会。

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引用次数: 3

Cryptococcosis with Mediastinal Lymph Node and Lung Involvement in an Immunocompetent Adolescent: A Case Report 免疫功能正常青少年隐球菌病伴纵隔淋巴结和肺部受累一例报告

Q3 Medicine

Pediatric Infection and Vaccine

Pub Date : 2021-08-01 DOI: 10.14776/piv.2021.28.e7

Jiyeon Lee, C. Cho, Hyun Cho, H. Park, Kyung-Hyo Kim

引用次数: 0

Evaluation of Interferon-gamma Release Assay in Children with Confirmed Tuberculosis 儿童结核确诊患者干扰素释放试验的评价

Q3 Medicine

Pediatric Infection and Vaccine

Pub Date : 2021-04-01 DOI: 10.14776/PIV.2021.28.E5

Kyu Ho Kim, Ji‐Man Kang, Jong Gyun Ahn

Purpose: This study aimed to evaluate the diagnostic value of the QuantiFERON-TB Gold InTube (QFT-GIT) in children with confirmed tuberculosis (TB). Methods: We retrospectively reviewed the medical records of children aged ≤18 years who underwent both QFT-GIT and Mycobacterium tuberculosis culture between 2006 and 2017. Confirmed TB was defined as the presence of at least one positive specimen for M. tuberculosis on culture or a nucleic acid amplification test. Results: Of the 582 patients included in the analysis, 48 were confirmed to have TB. The sensitivity and specificity of QFT-GIT for the diagnosis of confirmed TB were 85.4% and 95.5%, respectively. Among children with confirmed TB, the proportion in the immunocompromised state was higher in the QFT-GIT negative group than in the QFT-GIT positive group (50.0% vs. 5.7%, P=0.010). The median age at sampling was lower in the QFTGIT indeterminate group than in the QFT-GIT positive group (7 years vs. 17 years, P=0.008), and the proportion of immunosuppression was higher in the QFT-GIT indeterminate group than in the QFT-GIT positive group (42.9% vs. 5.7%, P=0.017). The interferon gamma response to mitogen control was significantly higher in the 10–18 years group than in the 0–9 years group (P<0.001), and was significantly higher in the immunocompetent group than in the immunocompromised group (P=0.001). Conclusion: The QFT-GIT results should be interpreted carefully in immunocompromised or younger children suspected of having TB.

目的：本研究旨在评估QuantiFERON TB金管（QFT-GIT）对儿童确诊结核病（TB）的诊断价值。方法：我们回顾性回顾了2006年至2017年间接受QFT-GIT和结核分枝杆菌培养的≤18岁儿童的医疗记录。确诊结核病是指在培养或核酸扩增测试中至少存在一个结核分枝杆菌阳性标本。结果：在纳入分析的582名患者中，48人被证实患有结核病。QFT-GIT诊断结核的敏感性和特异性分别为85.4%和95.5%。在确诊结核病的儿童中，QFT-GIT阴性组免疫功能低下的比例高于QFT-GIT阳性组（50.0%对5.7%，P=0.010）。QFTGIT不确定组的中位抽样年龄低于QFT-GI特阳性组（7岁对17岁，P=0.008），QFT-GIT不确定组的免疫抑制比例高于QFT-GIT阳性组（42.9%对5.7%，P=0.017）。10–18岁组对有丝分裂原控制的干扰素-γ反应显著高于0–9岁组（P<0.001），免疫功能组的QFT-GIT结果明显高于免疫功能低下组（P=0.001）。

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引用次数: 0

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