Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes

M. Remichkova, L. Mukova, L. Nikolaeva-Glomb, N. Nikolova, L. Doumanova, V. Mantareva, I. Angelov, V. Kussovski, A. Galabov
{"title":"Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes","authors":"M. Remichkova, L. Mukova, L. Nikolaeva-Glomb, N. Nikolova, L. Doumanova, V. Mantareva, I. Angelov, V. Kussovski, A. Galabov","doi":"10.1515/znc-2016-0119","DOIUrl":null,"url":null,"abstract":"Abstract Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5.","PeriodicalId":23894,"journal":{"name":"Zeitschrift für Naturforschung C","volume":"39 1","pages":"123 - 128"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Naturforschung C","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/znc-2016-0119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16

Abstract

Abstract Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
酞菁锌(II)配合物光动力作用下的病毒灭活
摘要:人们研究了各种金属酞菁对病毒的光动力作用。新合成的两种不同电荷的水溶性酞菁锌(II)配合物,阳离子甲基吡啶氧基取代锌(II)-酞菁(ZnPcMe)和阴离子磺胺氧基取代锌(II)-酞菁(ZnPcS),用于两种含dna的包膜病毒(单纯疱疹病毒1型和牛痘病毒)、两种含rna的包膜病毒(牛病毒性腹泻病毒和新城疫病毒)和两种裸病毒(柯萨奇B1肠病毒、一种含rna的病毒和人类腺病毒5,一种DNA病毒)。这两种带不同电荷的酞菁复合物对1型单纯疱疹病毒具有相同的显著杀病毒作用,在持续5或20分钟的照射下,1型单纯疱疹病毒是相同的(Δlog分别=3.0和4.0)。ZnPcMe对牛痘病毒的影响较低,Δlog=1.8, ZnPcS为2.0。牛病毒性腹泻病毒对ZnPcMe具有中等敏感性(Δlog=1.8),对ZnPcS具有显著敏感性(Δlog=5.8和5.3)。该复合物不能灭活新城疫病毒、柯萨奇病毒B1和人腺病毒5型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review Insecticidal effect of new synthesized chalcone derivatives on Caribbean fruit fly, Anastrepha suspensa Comparative analysis among the degradation potential of enzymes obtained from Escherichia coli against the toxicity of sulfur dyes through molecular docking Production, purification, and determination of the biochemical properties of β-glucosidase in Trichoderma koningii via solid substrate fermentation Investigating the anti-cancer compounds from Calliandra harrisii for precision medicine in pancreatic cancer via in-silico drug design and GC-MS analysis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1